General Information
Symbol
Dmel\Fancm0693
Species
D. melanogaster
Name
FlyBase ID
FBal0300932
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    point mutation
    Nucleotide change:
    T21482688A
    Reported nucleotide change:
    T?A
    Amino acid change:
    L82term | Fancm-PA; L82term | Fancm-PB
    Reported amino acid change:
    L?term
    Comment:
    The mutated base is the first base in the sequence TGGGAAAGACCTTCATTGCGGCGGTGGTTATGTACAACTTTT.
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Nucleotide substitution: T?A.
    Amino acid replacement: L?term.
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Model Data
    Disease Ontology
    Models ( 0 )
    Disease
    Evidence
    References
    Interactions ( 0 )
    Disease
    Interaction
    References
    Comments ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference
    Fancm0693/Fancmdel transheterozygous flies display significant increase in the number of spontaneous mitotic crossovers (assayed in males) and are sensitive gamma irradiation (low survival rate).
    Fancm0693/Df(3R)ED6058 animals are hyper-sensitive to the cross-linking agent HN2, the mono-adduct generator MMS, and ionizing radiation. Meiotic crossovers are elevated in Fancm0693/Df(3R)ED6058 animals, though only in a subset of the genome (centromere-proximal intervals). This elevation does not appear to have any negative impact on chromosome segregation. Spontaneous mitotic crossovers are elevated in Fancm0693/Df(3R)ED6058 males. Fancm0693/Df(3R)ED6058 animals show a decreased ability to complete 'synthesis-dependent strand annealing' repair of a DNA gap.
    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Enhanced by
    Suppressed by
    NOT suppressed by
    Enhancer of
    Statement
    Reference
    Other
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    The rate of spontaneous mitotic crossovers in BlmN1/BlmD2 Fancm0693/Df(3R)ED6058 males is not significantly different from that in Fancm0693/Df(3R)ED6058 males, but is significantly lower than in BlmN1/BlmD2 males. The rate of spontaneous mitotic crossovers in Fancm0693/Df(3R)ED6058 males is not affected if animals are also mutant for GenZ5997, mus81Nhe, slx1F93I or mei-9a, or if these animals are also mutant for both slx1F93I and mei-9a. However crossovers are completely or nearly absent in Fancm0693/Df(3R)ED6058 animals that are also mutant for mus312D1/mus312Z1973, or are also mutant for both mus81Nhe and slx1F93I.
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Partially rescued by
    Not rescued by
    Comments
    The increased number of mitotic crossovers as well as the low survival rate upon irradiation characteristic for Fancm0693/Fancmdel flies is rescued to a varying degree by combination with Fancm+tFL or FancmFLKM or Fancm1-645 but cannot be rescued by combination with Fancm1-645.K84M.
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (3)