FlyBase Allele Report: Dmel\Abca3[mir-1007-KO]

General Information

Symbol

Dmel\Abca3^mir-1007-KO

Species

D. melanogaster

Name

FlyBase ID

FBal0301893

Feature type

allele

Associated gene

Dmel\Abca3

Associated Insertion(s)

TI{TI}mir-1007^KO

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ends-out gene targeting

(Chen et al., 2014)

FLPase

(Chen et al., 2014)

I-SceI

(Chen et al., 2014)

cre recombinase

(Chen et al., 2014)

Progenitor genotype

Associated Insertion(s)

TI{TI}mir-1007^KO

Cytology

Description

The 8bp miRNA seed sequence of the mir-1007 miRtron has been deleted. A single loxP site is present at the site of the deletion. The expression of the ABCA host gene is also affected.

(Chen et al., 2014)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

ABCA^mir-1007-KO mutant stage 14 egg chambers do not display any pronounced nurse cell clearance defects and like in wild-type the germ-line derived nurse cells have undergone programmed cell death and been cleared by this stage.

(Santoso et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

Abca3^mir-1007-KO/Abca3^mir-1007-KO is an enhancer of egg chamber phenotype of Eato^f02254

(Santoso et al., 2018)

Abca3^mir-1007-KO/Abca3^mir-1007-KO is an enhancer of nurse cell phenotype of Eato^f02254

(Santoso et al., 2018)

Suppressor of

Statement

Reference

Abca3^mir-1007-KO/Abca3^mir-1007-KO is a suppressor | partially of egg chamber phenotype of Eato^MI14571

(Santoso et al., 2018)

Abca3^mir-1007-KO/Abca3^mir-1007-KO is a suppressor | partially of nurse cell phenotype of Eato^MI14571

(Santoso et al., 2018)

Additional Comments

Genetic Interactions

Statement

Reference

The nurse cell clearance defects observed in Eato^MI14571 mutant stage 14 egg chambers (which contain persistent nurse cell nuclei, while in wild-type egg chambers all the germ-line derived nurse cells have undergone programmed cell death and been cleared by this stage) is, surprisingly, ameliorated by ABCA^mir-1007-KO homozygosity, even though it strongly exacerbates this phenotype in Eato^f02254 mutant egg chambers.

(Santoso et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58885

w^* TI{TI}mir-1007^KO Abca3^mir-1007-KO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

ABCA^mir-1007-KO

Abca3^mir-1007-KO

CG1718^miR

(Santoso et al., 2018)

CG1718^mir-1007-KO

(Santoso et al., 2018)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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