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General Information
Symbol
Dmel\NAT1ex1
Species
D. melanogaster
Name
FlyBase ID
FBal0302232
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Excision of the progenitor insertion resulting in a 1.7kb genomic deletion that removes part of the first intron and 123bp at the 5' end of the second exon of NAT1 transcript 'a', and part of the first intron, all of the second exon and second intron, and 123bp at the 5' end of the third exon of NAT1 transcript 'b'.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Lethal from embryonic to pupal stages, with 16% of homozygotes dying at the embryonic stage and 60% at the pupal stage. Most pupae stopped development in the early pupal period, displaying a misshapen puparium. The majority of mutants fail to shorten their body to form the characteristic shape of a prepupa and form long prepupae instead, also failing to evert anterior spiracles. Very rare mutant animals reach pharate adult stage - these show abnormal body proportions, and some are headless. Larval wing, haltere and eye-antennal imaginal discs are significantly smaller than wild type.

NAT1ex1 mutants frequently have extra scutellar bristles on the scutellum.

In contrast to wild type where the larval salivary gland degenerates early in the pupal stage, the gross structure of the salivary gland is still intact 24h after puparium formation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

NAT1+t12.6 completely rescues the lethality associated with NAT1ex1.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
NAT1ex1
Name Synonyms
Secondary FlyBase IDs
    References (1)