FB2025_01 , released February 20, 2025
Allele: Dmel\Pex7MI14471
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General Information
Symbol
Dmel\Pex7MI14471
Species
D. melanogaster
Name
FlyBase ID
FBal0302311
Feature type
allele
Associated gene
Dmel\Pex7
Associated Insertion(s)
Mi{MIC}Pex7MI14471
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    Mi{MIC}Pex7MI14471
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    Mi{MIC}
    Also carries
    attP
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  Peroxisome biogenesis disorder 9B
        CEC
        (Di Cara et al., 2019)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        The few arrested pupae of Pex7MI14471/Pex7MI14471 and Pex7MI14471/Df(3L)BSC816 mutants have the same size as control pupae but exhibit developmental abnormalities.

        Pex7MI14471/Pex7MI14471 embryos show increased apoptosis, as compared to controls.

        Pex7MI14471/Pex7MI14471 larvae are longer than controls but developmental timing does not seem to be affected, as most animals reach the adult stage at the same time as control animals; their brains, however, are much smaller than controls, which is related with increased apoptosis instead of with decreased mitosis. Pex7MI14471/Df(3L)BSC816 larvae also show smaller brains with increased levels of apoptosis, as compared to controls.

        Pex7MI14471/Pex7MI14471 adults show a small but significant decrease in climbing ability, as compared to controls.

        (Di Cara et al., 2019)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Pex7MI14471
        (Di Cara et al., 2019, Bellen, 2015.2.9)
        Pex7MiMIC
        (Pridie and Simmonds, 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)