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General Information
Symbol
Dmel\EatoMI14571
Species
D. melanogaster
Name
FlyBase ID
FBal0302332
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference
    Insertion components
    Mi{MIC}EatoMI14571
    Product class / Tool use(s)
    Encoded product / tool
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease-implicated variant(s)
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    EatoMI14571 homozygous as well as Eatof02254/EatoMI14571 mutant stage 14 egg chambers show nurse cell clearance defect and contain on average 6 persistent nurse cell nuclei, while in wild-type egg chambers all the germ-line derived nurse cells have undergone programmed cell death and been cleared by this stage. St.14 egg chambers containing EatoMI14571 germ-line clones do not show significant clearance defects.

    Similarly, EatoMI14571/Df(2L)BSC812 mutants exhibit defects in engulfment of nurse cells by the follicle cells during starvation-induced programmed cell death: While phase 0 and phase 1 egg chambers resemble the control, in phase 3 eggs their follicle cells show fewer engulfed Dcp-1-positive vesicles and by phase 5 the dying mutant egg chambers display severe engulfment defects and follicle cell death, leaving behind completely unengulfed germline.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Suppressed by
    Enhancer of
    NOT Enhancer of
    Statement
    Reference
    Additional Comments
    Genetic Interactions
    Statement
    Reference

    The nurse cell clearance defect observed in EatoMI14571 mutant stage 14 egg chambers (which contain persistent nurse cell nuclei, while in wild-type egg chambers all the germ-line derived nurse cells have undergone programmed cell death and been cleared by this stage) is, surprisingly, ameliorated by ABCAmir-1007-KO homozygosity, even though it strongly exacerbates this phenotype in Eatof02254 mutant egg chambers.

    The nurse cell clearance defects characteristic for drprΔ5 mutant stage 14 egg chambers are not significantly exacerbated by combination with EatoMI14571 in homozygous state and both drprΔ5 single and EatoMI14571;drprΔ5 double mutant egg chambers display on average ~9 persistent nuclei. However, EatoMI14571 homozygosity does further impair the nurse cell engulfment defect seen in stage 14 egg chambers expressing Ced-12HM05042 under the control of Scer\GAL4GR1.

    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (1)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (3)
    Reported As
    Symbol Synonym
    Name Synonyms
    Secondary FlyBase IDs
      References (2)