FlyBase Allele Report: Dmel\ND-42[ninaE.GD6220]

FB2025_01 , released February 20, 2025

FB2025_01 , released February 20, 2025

Allele: Dmel\ND-42^ninaE.GD6220

General Information

Symbol

Dmel\ND-42^ninaE.GD6220

Species

D. melanogaster

Name

FlyBase ID

FBal0302644

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{ninaE-ND-42-GD6220}

Also Known As

Rh-ND42 RNAi, Rh:ND42 RNAi

Key Links

Transgenic product class

(Liu et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Liu et al., 2015)

Mutagen

in vitro construct

(Liu et al., 2015)

Progenitor genotype

Carried in construct

P{ninaE-ND-42-GD6220}

Cytology

Description

A ninaE promoter drives expression of dsRNA-GD6220.

(Liu et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell size | adult stage

(Goodman et al., 2024)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of ND-42^ninaE.GD6220 in photoreceptors induces formation of lipid droplets in the neighboring glial cells.

(Liu et al., 2017)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

ND-42^ninaE.GD6220, Scer\GAL4^54C, tau^HM05101 has abnormal cell size | adult stage phenotype

(Goodman et al., 2024)

Hsap\MAPT^UAS.cWa, ND-42^ninaE.GD6220, Scer\GAL4^54C has abnormal cell size | adult stage phenotype

(Goodman et al., 2024)

AP-2α^HMS00653, ND-42^ninaE.GD6220, Scer\GAL4^54C has abnormal neuroanatomy | adult stage phenotype

(Moulton et al., 2021)

AP-2α^HMS00653, ND-42^ninaE.GD6220, Scer\GAL4^54C has abnormal neurophysiology | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, Vps26^GD8448 has abnormal neurophysiology | adult stage | progressive phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, Vps35^HMS01858 has abnormal neurophysiology | adult stage | progressive phenotype

(Moulton et al., 2021)

LRP1^JF01628, ND-42^ninaE.GD6220, Scer\GAL4^54C has abnormal neuroanatomy | adult stage phenotype

(Moulton et al., 2021)

LRP1^JF01628, ND-42^ninaE.GD6220, Scer\GAL4^54C has abnormal neurophysiology | adult stage | progressive phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU, ldd^HMS01824 has abnormal neuroanatomy | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU, ldd^HMS01824 has abnormal neurophysiology | adult stage | progressive phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, lap^HMC02373 has abnormal neuroanatomy | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, lap^HMC02373 has abnormal neurophysiology | adult stage phenotype

(Moulton et al., 2021)

Eato^HMC06027, ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has abnormal neuroanatomy | adult stage phenotype

(Moulton et al., 2021)

Eato^HMC06027, ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has abnormal neurophysiology | adult stage | progressive phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, cindr^HMS01795 has abnormal neuroanatomy | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, cindr^HMS01795 has abnormal neurophysiology | adult stage phenotype

(Moulton et al., 2021)

Phenotype Manifest In

Enhanced by

Statement

Reference

GLaz[+]/GLaz^{MI02243-TG4.0}, ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Hsap\APOE^{2.C112.C158.UAS}/Scer\GAL4^{GLaz-MI02243-TG4.0}

(Liu et al., 2017)

GLaz[+]/GLaz^{MI02243-TG4.0}, ND-42^ninaE.GD6220 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Hsap\APOE^{2.C112.C158.UAS}/Scer\GAL4^{GLaz-MI02243-TG4.0}

(Liu et al., 2017)

GLaz[+]/GLaz^{MI02243-TG4.0}, ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Hsap\APOE^{3.C112.R158.UAS}/Scer\GAL4^{GLaz-MI02243-TG4.0}

(Liu et al., 2017)

GLaz[+]/GLaz^{MI02243-TG4.0}, ND-42^ninaE.GD6220 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Hsap\APOE^{3.C112.R158.UAS}/Scer\GAL4^{GLaz-MI02243-TG4.0}

(Liu et al., 2017)

GLaz[+]/GLaz^{MI02243-TG4.0}, ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, enhanceable by Scer\GAL4^{GLaz-MI02243-TG4.0}/Hsap\APOE^{4.R112.R158.UAS}

(Liu et al., 2017)

GLaz[+]/GLaz^{MI02243-TG4.0}, ND-42^ninaE.GD6220 has lipid droplet | adult stage | cell non-autonomous phenotype, enhanceable by Scer\GAL4^{GLaz-MI02243-TG4.0}/Hsap\APOE^{4.R112.R158.UAS}

(Liu et al., 2017)

NOT Enhanced by

Statement

Reference

ND-42^ninaE.GD6220 has lipid droplet | adult stage | increased number phenotype, non-enhanceable by tau^{CR70012-TG4.0}/Hsap\MAPT^{1xUAS.0N4R.EGFP}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, non-enhanceable by tau^{CR70012-TG4.0}/Hsap\MAPT^{1xUAS.0N4R.EGFP}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | adult stage | increased number phenotype, non-enhanceable by Scer\GAL4^ninaE.PU/Hsap\MAPT^UAS.cWa

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, non-enhanceable by Scer\GAL4^ninaE.PU/Hsap\MAPT^UAS.cWa

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | adult stage | increased number phenotype, non-enhanceable by Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, non-enhanceable by Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS

(Goodman et al., 2024)

Suppressed by

Statement

Reference

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by tau^HM05101/Scer\GAL4^54C

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by tau^HM05101/Scer\GAL4^54C

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by futsch^N94/futsch[+]

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by futsch^N94/futsch[+]

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by ens[+]/ens^ΔC

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by ens[+]/ens^ΔC

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by Scer\GAL4^54C/futsch^EP1419

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by Scer\GAL4^54C/futsch^EP1419

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible | partially by Scer\GAL4^54C/ens^UAS.Tag:HA

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible | partially by Scer\GAL4^54C/ens^UAS.Tag:HA

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by Scer\GAL4^54C/Hsap\MAPT^UAS.cWa

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by Scer\GAL4^54C/Hsap\MAPT^UAS.cWa

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by Scer\GAL4^54C/Hsap\MAPT^R406W.UAS

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by Scer\GAL4^54C/Hsap\MAPT^R406W.UAS

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible | partially by Scer\GAL4^54C/Hsap\MAPT^{S262D.UAS.0N4R.cIAa}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible | partially by Hsap\MAPT^{S262E.UAS.0N4R.cIAa}/Scer\GAL4^54C

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by Scer\GAL4^54C/Hsap\MAPT^{S262A.UAS.0N4R.cIAa}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible | partially by Scer\GAL4^54C/Hsap\MAPT^{S262D.UAS.0N4R.cIAa}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible | partially by Hsap\MAPT^{S262E.UAS.0N4R.cIAa}/Scer\GAL4^54C

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by Scer\GAL4^54C/Hsap\MAPT^{S262A.UAS.0N4R.cIAa}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}/Hsap\MAPT^{A152T.1xUAS.2N4R}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}/Hsap\MAPT^{A152T.1xUAS.2N4R}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}/Hsap\MAPT^{R406W.1xUAS.2N4R}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}/Scer\GAL4^{tau-CR70012-TG4.0}/Hsap\MAPT^{P301S.1xUAS.2N4R}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}/Scer\GAL4^{tau-CR70012-TG4.0}/Hsap\MAPT^{P301S.1xUAS.2N4R}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, suppressible by tau^{CR70012-TG4.0}/Hsap\MAPT^{R406W.1xUAS.2N4R}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, suppressible by Eato^HMC06027, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, suppressible by Eato^HMC06027, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, suppressible by ldd^HMS01824, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, suppressible by ldd^HMS01824, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, suppressible by LRP1^JF01628, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, suppressible by LRP1^JF01628, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, suppressible by Vps26^GD8448, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, suppressible by Vps26^GD8448, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, suppressible by Vps26^GD8448, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, suppressible by Vps26^GD8448, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, suppressible by Vps35^HMS01858, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, suppressible by Vps35^HMS01858, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, suppressible by Vps35^HMS01858, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, suppressible by Vps35^HMS01858, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, suppressible by cindr^HMS01795, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, suppressible by cindr^HMS01795, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, suppressible by AP-2α^HMS00653, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, suppressible by AP-2α^HMS00653, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, suppressible by lap^HMC02373, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, suppressible by lap^HMC02373, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Ldh^HMS00039/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Ldh^HMS00039/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Fatp1^KK104809/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Fatp1^KK104809/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^elav.PLu/Fatp1^HMC03111

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^elav.PLu/Fatp1^HMC03111

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Fatp1^HMC03960/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Fatp1^HMC03960/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Fatp1^HMC04206/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Fatp1^HMC04206/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^elav.PLu/NLaz^GD12709

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^elav.PLu/NLaz^GD12709

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by NLaz^KK107553/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by NLaz^KK107553/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible | partially by Pdha1^A/Pdha[+]

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible | partially by Pdha1^A/Pdha[+]

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible | partially by kdn[+]/Cs1^A

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible | partially by kdn[+]/Cs1^A

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible | partially by GLaz[+]/GLaz^{MI02243-TG4.0}

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible | partially by GLaz[+]/GLaz^{MI02243-TG4.0}

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^54C/Bsg^GD989

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^54C/Bsg^GD989

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^54C/Bsg^GD15718

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^54C/Bsg^GD15718

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Ldh^HMS00039/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Ldh^HMS00039/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^54C/Fatp1^KK104809

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^54C/Fatp1^KK104809

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^54C/Fatp1^HMC03111

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^54C/Fatp1^HMC03111

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Fatp1^HMC03960/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Fatp1^HMC03960/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^54C/Fatp1^HMC04206

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^54C/Fatp1^HMC04206

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by GLaz^GD4806/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by GLaz^GD4806/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^54C/GLaz^KK106377

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^54C/GLaz^KK106377

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Sln^KK104306/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Sln^KK104306/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Sln^GD1940/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Sln^GD1940/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^elav.PLu/out^GD3448

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^elav.PLu/out^GD3448

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by out^KK104187/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by out^KK104187/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Bsg^GD989/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Bsg^GD989/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Scer\GAL4^elav.PLu/Bsg^GD15718

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Scer\GAL4^elav.PLu/Bsg^GD15718

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Pdha1^GD12103/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Pdha1^GD12103/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, suppressible by Pdha1^KK101856/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, suppressible by Pdha1^KK101856/Scer\GAL4^elav.PLu

(Liu et al., 2017)

NOT suppressed by

Statement

Reference

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, non-suppressible by Scer\GAL4^ninaE.PU/Hsap\MAPT^UAS.cWa

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, non-suppressible by Scer\GAL4^ninaE.PU/Hsap\MAPT^UAS.cWa

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, non-suppressible by Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, non-suppressible by Scer\GAL4^ninaE.PU/Hsap\MAPT^R406W.UAS

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has lipid droplet | increased number | adult stage phenotype, non-suppressible by tau^{CR70012-TG4.0}/Hsap\MAPT^{1xUAS.0N4R.EGFP}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220 has ommatidium | adult stage phenotype, non-suppressible by tau^{CR70012-TG4.0}/Hsap\MAPT^{1xUAS.0N4R.EGFP}/Scer\GAL4^{tau-CR70012-TG4.0}

(Goodman et al., 2024)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by Abca3^HMS01821, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by Abca3^HMS01821, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by CG31213^HMC04934, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by CG1494^HMC04971, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by CG8908^GL01278, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by CG1494^HMC04971, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by CG8908^GL01278, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by CG31213^HMC04934, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, non-suppressible by Eato^HMC06027, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, non-suppressible by Eato^HMC06027, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, non-suppressible by ldd^HMS01824, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, non-suppressible by ldd^HMS01824, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by LRP1^JF01628, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by LRP1^JF01628, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by LpR2^JF01627, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by LpR2^JF01627, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, non-suppressible by LpR2^JF01627, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, non-suppressible by LpR2^JF01627, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by cindr^HMS01795, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by cindr^HMS01795, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by AP-2α^HMS00653, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by AP-2α^HMS00653, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by lap^HMC02373, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by lap^HMC02373, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by Amph^HMJ21356, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by Amph^HMJ21356, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, non-suppressible by Amph^HMJ21356, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, non-suppressible by Amph^HMJ21356, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has lipid droplet | adult stage phenotype, non-suppressible by spri^KK105547, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has pigment cell | adult stage phenotype, non-suppressible by spri^KK105547, Scer\GAL4^ninaE.PU

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has lipid droplet | adult stage phenotype, non-suppressible by spri^KK105547, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C has pigment cell | adult stage phenotype, non-suppressible by spri^KK105547, Scer\GAL4^54C

(Moulton et al., 2021)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Sln^KK104306/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Sln^KK104306/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/shakB^HMC04895

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/shakB^HMC04895

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/Pdha1^GD12103

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/Pdha1^GD12103

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Pdha1^KK101856/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Pdha1^KK101856/Scer\GAL4^54C

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/NLaz^GD12709

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/NLaz^GD12709

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/NLaz^KK107553

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/NLaz^KK107553

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/Sln^GD1940

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^elav.PLu/shakB^GD12666

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^elav.PLu/shakB^GD12666

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by shakB^HMC04895/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by shakB^HMC04895/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by GLaz^GD4806/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by GLaz^GD4806/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by GLaz^KK106377/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by GLaz^KK106377/Scer\GAL4^elav.PLu

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/Sln^GD1940

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/out^GD3448

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/out^GD3448

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/out^KK104187

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/out^KK104187

(Liu et al., 2017)

ND-42^ninaE.GD6220 has adult optic lobe glial cell | cell non-autonomous phenotype, non-suppressible by Scer\GAL4^54C/shakB^GD12666

(Liu et al., 2017)

ND-42^ninaE.GD6220 has lipid droplet | cell non-autonomous | adult stage phenotype, non-suppressible by Scer\GAL4^54C/shakB^GD12666

(Liu et al., 2017)

Other

Statement

Reference

ND-42^ninaE.GD6220, Scer\GAL4^54C, tau^HM05101 has vacuole | adult stage phenotype

(Goodman et al., 2024)

ND-42^ninaE.GD6220, Scer\GAL4^54C, tau^HM05101 has adult glial cell phenotype

(Goodman et al., 2024)

Hsap\MAPT^UAS.cWa, ND-42^ninaE.GD6220, Scer\GAL4^54C has vacuole | adult stage phenotype

(Goodman et al., 2024)

Hsap\MAPT^UAS.cWa, ND-42^ninaE.GD6220, Scer\GAL4^54C has adult glial cell phenotype

(Goodman et al., 2024)

ND-42^ninaE.GD6220, Scer\GAL4^54C, cindr^HMS01795 has rhabdomere | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, cindr^HMS01795 has retina | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, Vps26^GD8448 has retina | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, Vps35^HMS01858 has retina | adult stage phenotype

(Moulton et al., 2021)

AP-2α^HMS00653, ND-42^ninaE.GD6220, Scer\GAL4^54C has rhabdomere | adult stage phenotype

(Moulton et al., 2021)

LRP1^JF01628, ND-42^ninaE.GD6220, Scer\GAL4^54C has rhabdomere | adult stage phenotype

(Moulton et al., 2021)

LRP1^JF01628, ND-42^ninaE.GD6220, Scer\GAL4^54C has retina | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU, ldd^HMS01824 has rhabdomere | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU, ldd^HMS01824 has retina | adult stage phenotype

(Moulton et al., 2021)

AP-2α^HMS00653, ND-42^ninaE.GD6220, Scer\GAL4^54C has retina | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, lap^HMC02373 has rhabdomere | adult stage phenotype

(Moulton et al., 2021)

ND-42^ninaE.GD6220, Scer\GAL4^54C, lap^HMC02373 has retina | adult stage phenotype

(Moulton et al., 2021)

Eato^HMC06027, ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has rhabdomere | adult stage phenotype

(Moulton et al., 2021)

Eato^HMC06027, ND-42^ninaE.GD6220, Scer\GAL4^ninaE.PU has retina | adult stage phenotype

(Moulton et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of lipid droplets in glial cells in the vicinity of adult photoreceptor neurons expressing ND-42^ninaE.GD6220 is not suppressed by Scer\GAL4^54C-driven (glial) expression of any of the following: Sln^KK104306, Sln^GD1940, out^GD3448, out^KK104187, shakB^GD12666, shakB^HMC04895, Pdha^GD12103, Pdha^KK101856 while expression of any of these transgenes - with the exception of shakB^GD12666 and shakB^HMC04895 - under the control of the neuronal Scer\GAL4^elav.PLu driver efficiently rescues the phenotype. Expression of Bsg^GD989, Bsg^GD15718, Ldh^HMS00039, Fatp^KK104809, Fatp^HMC03111, Fatp^HMC03960 or Fatp^HMC04206 ameliorates the lipid accumulation in glial cells when driven by either Scer\GAL4^54C or Scer\GAL4^elav.PLu. Glial (but not neuronal) knock-down of GLaz using GLaz^GD4806 or GLaz^KK106377 reduces the droplet build-up, while only the neuronal (and not glial) RNAi of NLaz using NLaz^GD12709 or NLaz^KK107553 does so.

The glial lipid droplets accumulation in ND-42^ninaE.GD6220 flies is also lessened by combination with a single copy of either Pdha^A, kdn^A or GLaz^{MI02243-TG4.0}.

(Liu et al., 2017)

Xenogenetic Interactions

Statement

Reference

The amelioration of lipid droplet accumulation in glial cells in the retina of adult flies expressing ND-42^ninaE.GD6220 observed upon combination with a single copy of GLaz^{MI02243-TG4.0} is negated, to a varying extent (and the number of droplets significantly increased again), by Scer\GAL4^{GLaz-MI02243-TG4.0}-driven (a driver inherent to the GLaz^{MI02243-TG4.0} allele) expression of any of the following: Hsap\APOE^{2.C112.C158.UAS}, Hsap\APOE^{3.C112.R158.UAS} or Hsap\APOE^{4.R112.R158.UAS}.

(Liu et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

76598

w^*; P{ninaE-ND-42-GD6220}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ND-42^ninaE.GD6220

Name Synonyms

Secondary FlyBase IDs

References (4)

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