Open Close
General Information
Symbol
Dmel\azotKO
Species
D. melanogaster
Name
FlyBase ID
FBal0302673
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
complex substitution
Comment:

The azot coding region has been deleted by homologous recombination and replaced with an attP site and P1\loxP-flanked w marker. The boundaries of the deleted region were inferred from primer sequences.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The azot coding region has been deleted and replaced with an attP site and a loxP-flanked w[+] marker.

Insertion components
TI{TI}azotKO
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

These mutants are short lived compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The loss of 'loser' cell elimination seen in azotKO mutant cells following dm-induced cell competition is rescued upon expression of azotT:Disc\RFP.

Expression of two copies of azotT:Disc\RFP rescues the wing defects seen in homozygous azotKO mutant flies.

Expression of two copies of azotT:Disc\RFP rescues the increase in vacuoles seen in azotKO mutant brains.

Expression of two copies of azotT:Disc\RFP rescues the reduced lifespan seen in azotKO mutant brains.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)