FB2025_05 , released December 11, 2025
Allele: Dmel\CycE1F36
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General Information
Symbol
Dmel\CycE1F36
Species
D. melanogaster
Name
FlyBase ID
FBal0302716
Feature type
allele
Associated gene
Dmel\CycE
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Wang and Kalderon, 2009)
Mutagen
chemical
(Wang and Kalderon, 2009)
ethyl methanesulfonate
(Unhavaithaya et al., 2013)
Progenitor genotype
Cytology
Description

Amino acid replacement: G249E.

(Unhavaithaya et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:15,730,127..15,730,127 [-]
Nucleotide change:

G15730127A

Amino acid change:

G356E | CycE-PA; G249E | CycE-PB; G356E | CycE-PC; G356E | CycE-PD; G356E | CycE-PE; G359E | CycE-PF

Reported amino acid change:

G?E

Reported amino acid change:

G249E

Comment:

Gly to Glu substitution near the conserved MRAIL substrate recognition motif.

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The amino acid position of the mutation was reported relative to CycE-PB.

(Unhavaithaya et al., 2013, Park et al., 2007)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      No transformation of the NB6-4t neuroblast to NB6-4a is seen in homozygous embryos.

      (Unhavaithaya et al., 2013)

      CycE1F36 clones do not impair germ line stem cell maintenance. However, CycE2 clones engender follicle stem cells defects.

      (Wang and Kalderon, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      CycE05206

      (Unhavaithaya et al., 2013)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      1F36
      (Wang and Kalderon, 2009)
      CycE1F36
      CycE1f36
      cyclin E1f36
      (Unhavaithaya et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0241969
      • FBal0295895
      References (3)