FB2025_01 , released February 20, 2025
Allele: Dmel\lncRNA:acalUAS.cRa
Open Close
General Information
Symbol
Dmel\lncRNA:acalUAS.cRa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Rios-Barrera
FlyBase ID
FBal0302951
Feature type
allele
Associated gene
Dmel\lncRNA:acal
Associated Insertion(s)
Carried in Construct
P{UAS-acal.R}
Key Links
Transgenic product class
cDNA
(Ríos-Barrera et al., 2015)
wild_type
(Ríos-Barrera et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Ríos-Barrera et al., 2015)
wild_type
(Ríos-Barrera et al., 2015)
Mutagen
in vitro construct
(Ríos-Barrera et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-acal.R}
Cytology
Description

UAS regulatory sequences drive expression of the 2.3kb lncRNA:acal cDNA (SD08925).

(Ríos-Barrera et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
lncRNA:acal
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of acalScer\UAS.cRa under the control of Scer\GAL469B in a wild type background has no dorsal closure effects. Flies expressing acalScer\UAS.cRa under the control of Scer\GAL4pnr-MD237 show no lethality or overt phenotypes.

      Expression of two copies of acalScer\UAS.cRa under the control of Scer\GAL4pnr-MD237 results in an increase in the frequency of thoracic clefts in adult flies compared to controls. No phenotypes are observed with one copy of Scer\GAL4pnr-MD237.

      (Ríos-Barrera et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of acalScer\UAS.cRa under the control of Scer\GAL469B partially suppresses the cuticle dorsalization phenotype seen in raw2 mutant embryos.

      Expression of rawScer\UAS.P\T.cJa enhances the increase in the frequency of thoracic clefts in adult flies seen when acalScer\UAS.cRa is expressed under the control of Scer\GAL4pnr-MD237.

      Expression of rawScer\UAS.P\T.cJb enhances the increase in the frequency of thoracic clefts in adult flies seen when acalScer\UAS.cRa is expressed under the control of Scer\GAL4pnr-MD237.

      (Ríos-Barrera et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      lncRNA:acalUAS.cRa/Scer\GAL469B partially rescues lncRNA:acal5

      (Ríos-Barrera et al., 2015)
      Comments

      Expression of acalScer\UAS.cRa under the control of Scer\GAL469B results in significant rescue of acal5 dorsal closure defects and reduction of embryonic lethality.

      Expression of acalScer\UAS.cRa under the control of Scer\GAL4pnr-MD237 rescues acal5 dorsal closure defects.

      (Ríos-Barrera et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      acalScer\UAS.cRa
      lncRNA:acalScer\UAS.cRa
      lncRNA:acalUAS.cRa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Rios-Barrera
      Secondary FlyBase IDs
        References (1)