Mating of wild-type females to males expressing CG10433^Scer\UAS.cLa under the control of either Scer\GAL4^Act.PU or Scer\GAL4^nos.PU results in a decrease in embryonic hatch rate and an increase in embryonic lethality.

Embryos from wild-type females mated with CG10433^Scer\UAS.cLa-overexpressing males display numerous abnormalities, including asynchronous cleavage, unevenly distributed nuclei and different sizes of the nuclei. In individual embryos, three highly correlated major defects are observed. First, smaller and narrower metaphase spindles appear in the syncytial blastoderms, which are very similar to haploid metaphase spindles. Second, centrosomes often dissociate from mitotic spindles. Thirdly, the spindles exhibit a strange morphology with a regular couple of tubulin-containing particles in the middle of the divided chromosomes at telophase.

Like Wolbachia-infected males, CG10433^Scer\UAS.cLa-expressing males (under the control of Scer\GAL4^nos.PU or Scer\GAL4^Act.PU) may inhibit the receptivity to remating in mated wild-type females.