FB2025_01 , released February 20, 2025
Allele: Zzzz\GGGGCC3.UAS
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General Information
Symbol
Zzzz\GGGGCC3.UAS
Species
a. artificial
Name
FlyBase ID
FBal0304407
Feature type
allele
Associated gene
Zzzz\GGGGCC
Associated Insertion(s)
Carried in Construct
P{UAS-GGGGCC.3}
Also Known As
UAS-G4C2x3, G4C2-3, UAS-(G4C2)3
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Mizielinska et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-GGGGCC.3}
Cytology
Description

UAS regulatory sequences drive expression of 3 pure repeats of Zzzz\GGGGCC.

(Mizielinska et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Zzzz\GGGGCC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Zzzz\GGGGCC3.Scer\UAS does not lead to any significant defects in adult eye morphology (Scer\GAL4GMR.PF-driven expression), larval locomotion in crawling assays (Scer\GAL4nSyb.PS-driven expression), or adult locomotion activity in climbing assays (Scer\GAL4da.G32-driven expression), as compared to controls.

      (Hautbergue et al., 2017)

      The expression of Zzzz\GGGGCC3.UAS under the control of Scer\GAL4CCAP.PI leads a significant decrease in the axonal transport of (NPY-positive) vesicles (i.e. a significant decrease in anterograde transport and a significant increase in the stationary fraction), but not of mitochondria, in third instar larval motor neurons, as compared to controls.

      Expression under the control of Scer\GAL4Toll-6-D42 does not lead to any changes in larval or adult locomotion (in climbing and crawling assays, respectively), as compared to controls.

      (Baldwin et al., 2016)

      Constitutive expression of Zzzz\GGGGCC3.Scer\UAS in the eye using Scer\GAL4GMR.PU has no effect.

      (Mizielinska et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (6)
      Reported As
      Symbol Synonym
      G4C2-3
      (Baldwin et al., 2016)
      G4C2-3
      (Cacciottolo et al., 2019)
      Zzzz\GGGGCC3.Scer\UAS
      Zzzz\GGGGCC3.UAS
      Zzzz\poly-GP3.Scer\UAS
      Zzzz\poly-GR3.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0300892
      • FBal0300900
      References (14)