FlyBase Allele Report: Zzzz\GGGGCC[36.UAS]

General Information

Symbol

Zzzz\GGGGCC^36.UAS

Species

a. artificial

Name

FlyBase ID

FBal0304408

Feature type

allele

Associated gene

Zzzz\GGGGCC

Associated Insertion(s)

Carried in Construct

P{UAS-GGGGCC.36}

Also Known As

UAS-(G₄C₂)₃₆, UAS-36R, UAS-(G4C2)36, UAS-G4C2x36, G₄C₂-36

Transgenic product class

short_tandem_repeat_expansion

(Mizielinska et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

short_tandem_repeat_expansion

(Mizielinska et al., 2014)

Mutagen

in vitro construct

(Mizielinska et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-GGGGCC.36}

Cytology

Description

UAS regulatory sequences drive expression of 36 pure repeats of Zzzz\GGGGCC.

(Mizielinska et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Zzzz\GGGGCC

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis

CEA

(Hautbergue et al., 2017, Mizielinska et al., 2014)

model of frontotemporal dementia

CEA

(Mizielinska et al., 2014)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

CEA

(Lee et al., 2024, Catterson et al., 2023, Xu et al., 2023, Farrugia et al., 2022, Licata et al., 2022, Atilano et al., 2021, Castelli et al., 2021, Kim et al., 2021, Cunningham et al., 2020, Ortega et al., 2020, Ramesh et al., 2020, Moens et al., 2019, Tran et al., 2015)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of amyotrophic lateral sclerosis

is ameliorated by SF2^GD12097

(Hautbergue et al., 2017)

is NOT ameliorated by Ref1^KK109076

(Hautbergue et al., 2017)

is NOT ameliorated by Ref1^GD4683

(Hautbergue et al., 2017)

model of frontotemporal dementia and/or amyotrophic lateral sclerosis 1

is exacerbated by e(y)2^KK102036

(Ortega et al., 2020)

is exacerbated by eRF1^GD4704

(Ortega et al., 2020)

is exacerbated by Art1^KK101196

(Ortega et al., 2020)

is exacerbated by CCT8^KK100186

(Ortega et al., 2020)

is ameliorated by SF2^GD12097

(Castelli et al., 2021, Ortega et al., 2020)

is exacerbated by Tnpo-SR^GD9833

(Ortega et al., 2020)

is ameliorated by ref(2)P^HMS00551

(Cunningham et al., 2020)

is ameliorated by ref(2)P^HMS00938

(Cunningham et al., 2020)

is exacerbated by ref(2)P^UAS.Tag:HA

(Cunningham et al., 2020)

is ameliorated by eIF1A^UAS.ORF

(Moens et al., 2019)

is ameliorated by Akt^{T342D.S505D.GMR}

(Atilano et al., 2021)

is exacerbated by InR^K1409A.UAS

(Atilano et al., 2021)

is ameliorated by SK^MI09020

(Castelli et al., 2021)

is ameliorated by SK^MI10378

(Castelli et al., 2021)

is ameliorated by Hsap\MATR3^UAS.Tag:FLAG

(Ramesh et al., 2020)

is ameliorated by Pka-C1^KK108966

(Licata et al., 2022)

is ameliorated by Pka-C1^VSH330111

(Licata et al., 2022)

is exacerbated by LanB1^EP-600

(Catterson et al., 2023)

is exacerbated by chk^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

is ameliorated by bumpel^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal eye color | adult stage, with Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

abnormal locomotor behavior | adult stage, with Scer\GAL4^da.G32

(Hautbergue et al., 2017)

abnormal locomotor behavior | adult stage, with Scer\GAL4^GMR.PU

(Ortega et al., 2020)

abnormal locomotor behavior | adult stage | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Atilano et al., 2021)

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^nSyb.PS

(Hautbergue et al., 2017)

decreased size | adult stage, with Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

increased cell death | adult stage, with Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

increased rate of adult locomotory behavior | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

increased sleep | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Atilano et al., 2021)

lethal | heat sensitive, with Scer\GAL4^GMR.PU

(Mizielinska et al., 2014)

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023, Xu et al., 2023, Atilano et al., 2021, Mizielinska et al., 2014)

visible, with Scer\GAL4^GMR.PU

(Mizielinska et al., 2014)

visible | adult stage, with Scer\GAL4^GMR.PF

(Ramesh et al., 2020, Hautbergue et al., 2017)

visible | adult stage, with Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

visible | adult stage, with Scer\GAL4^GMR.PU

(Ortega et al., 2020, Tran et al., 2015)

Phenotype Manifest In

autolysosome | adult stage | increased number | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

embryonic/larval motor neuron | third instar larval stage, with Scer\GAL4^CCAP.PU

(Baldwin et al., 2016)

eye, with Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

eye, with Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

eye, with Scer\GAL4^GMR.PU

(Ortega et al., 2020, Mizielinska et al., 2014)

eye | adult stage, with Scer\GAL4^GMR.PF

(Hautbergue et al., 2017)

eye | adult stage, with Scer\GAL4^GMR.PU

(Tran et al., 2015)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

ommatidium, with Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

Detailed Description

Statement

Reference

The expression of Zzzz\GGGGCC^36.UAS under the control of Scer\GAL4^GMR.PFa induces a small eye.

The expression of Zzzz\GGGGCC^36.UAS under the control of Scer\GAL4^{elav.Switch.PO} during adulthood (induced by RU486 feeding) are short lived and show decreased activity and increased sleep.

(Atilano et al., 2021)

Expression of Zzzz\GGGGCC^36.UAS under the control of Scer\GAL4^GMR.PU leads to motor dysfunction (climbing assay) and degeneration, necrotic patches, and depigmentation in the eyes.

(Ortega et al., 2020)

The expression of Zzzz\GGGGCC^36.UAS under the control of Scer\GAL4^GMR.PF external eye degeneration including ommatidial fusion, bristle disorganization, depigmentation, and necrotic patches.

(Ramesh et al., 2020)

The expression of Zzzz\GGGGCC^36.Scer\UAS leads to a rough eye phenotype (Scer\GAL4^GMR.PF-driven expression) and to significant decreases in both larval locomotor activity in crawling assays (Scer\GAL4^nSyb.PS-driven expression) and adult locomotor activity in climbing assays (Scer\GAL4^da.G32-driven expression), as compared to controls.

(Hautbergue et al., 2017)

The expression of Zzzz\GGGGCC^36.UAS under the control of Scer\GAL4^CCAP.PI leads a significant decrease in the axonal transport of both mitochondria (i.e. a significant decrease in retrograde transport and a significant increase in the stationary fraction) and (NPY-positive) vesicles (i.e. a significant decrease in anterograde transport and a significant increase in the stationary fraction), in third instar larval motor neurons, as compared to controls.

Expression under the control of Scer\GAL4^Toll-6-D42 does not lead to any changes in larval or adult locomotion (in climbing and crawling assays, respectively), as compared to controls.

(Baldwin et al., 2016)

Expression of Zzzz\GGGGCC^36.Scer\UAS under the control of Scer\GAL4^GMR.PU results in eye-degenerative phenotype.

(Tran et al., 2015)

Constitutive expression of Zzzz\GGGGCC^36.Scer\UAS in the eye using Scer\GAL4^GMR.PU causes eye degeneration. Increasing expression levels of the pure repeats by increasing the temperature leads to lethality.

Adult-onset expression of Zzzz\GGGGCC^36.Scer\UAS under the control of Scer\GAL4^{elav.Switch.PO} (in combination with RU486 treatment) kills all flies by 30 days after eclosion.

(Mizielinska et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, enhanceable by LanB1^EP-600, Scer\GAL4^{elav.Switch.PO}

(Catterson et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, enhanceable by Atg1^HMS02750, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, enhanceable by InR^K1409A.UAS, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has decreased size | adult stage phenotype, enhanceable by InR^K1409A.UAS, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, enhanceable by InR^K1409A.UAS, Scer\GAL4^{elav.Switch.PO}

(Atilano et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, enhanceable by eRF1^GD4704/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, enhanceable by Art1^KK101196, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, enhanceable by Upf1^HMC05537/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | adult stage phenotype, enhanceable by eRF1^GD4704/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, enhanceable by CCT8^KK100186, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, enhanceable by e(y)2^KK102036/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, enhanceable by Tnpo-SR^GD9833/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

NOT Enhanced by

Statement

Reference

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, non-enhanceable by Atg1^HMS02750/bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, non-enhanceable by Atg1^GS10797, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Suppressed by

Statement

Reference

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has increased rate of adult locomotory behavior | RU486 conditional phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, suppressible by Atg1^GS10797/bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible by InR^A1325D.UAS, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has decreased size | adult stage phenotype, suppressible by InR^A1325D.UAS, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible | partially by Akt^{T342D.S505D.GMR}, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has decreased size | adult stage phenotype, suppressible | partially by Akt^{T342D.S505D.GMR}, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible | partially by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has decreased size | adult stage phenotype, suppressible | partially by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, suppressible by InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO}

(Atilano et al., 2021)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | adult stage | RU486 conditional phenotype, suppressible by InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO}

(Atilano et al., 2021)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has increased sleep | RU486 conditional phenotype, suppressible by InR^A1325D.UAS, Scer\GAL4^{elav.Switch.PO}

(Atilano et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible by SF2^GD12097, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible by Hsap\ETF1^UAS.cOe, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible by Upf1^G1161/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible by Hsap\MATR3^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has abnormal eye color | adult stage phenotype, suppressible by Hsap\MATR3^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has increased cell death | adult stage phenotype, suppressible by Hsap\MATR3^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

Scer\GAL4^da.G32, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | adult stage phenotype, suppressible by SF2^GD12097, Scer\GAL4^da.G32

(Hautbergue et al., 2017)

Scer\GAL4^da.G32, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | adult stage phenotype, suppressible by sbr^HM05135/Scer\GAL4^da.G32

(Hautbergue et al., 2017)

Scer\GAL4^nSyb.PS, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | third instar larval stage phenotype, suppressible | partially by SF2^GD12097, Scer\GAL4^nSyb.PS

(Hautbergue et al., 2017)

Scer\GAL4^nSyb.PS, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | third instar larval stage phenotype, suppressible by sbr^HM05135/Scer\GAL4^nSyb.PS

(Hautbergue et al., 2017)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, suppressible by SF2^GD12097, Scer\GAL4^GMR.PF

(Hautbergue et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, non-suppressible by Scer\GAL4^{elav.Switch.PO}/hrm^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, non-suppressible by Atg1^HMS02750/bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, non-suppressible by Atg1^GS10797, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, non-suppressible by Scer\GAL4^{elav.Switch.PO}/chk^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has short lived | RU486 conditional phenotype, non-suppressible by Scer\GAL4^{elav.Switch.PO}/out^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Scer\GAL4^da.G32, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Ref1^KK109076, Scer\GAL4^da.G32

(Hautbergue et al., 2017)

Scer\GAL4^da.G32, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | adult stage phenotype, non-suppressible by Ref1^GD4683, Scer\GAL4^da.G32

(Hautbergue et al., 2017)

Scer\GAL4^nSyb.PS, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | third instar larval stage phenotype, non-suppressible by Ref1^KK109076, Scer\GAL4^nSyb.PS

(Hautbergue et al., 2017)

Scer\GAL4^nSyb.PS, Zzzz\GGGGCC^36.UAS has abnormal locomotor behavior | third instar larval stage phenotype, non-suppressible by Ref1^GD4683, Scer\GAL4^nSyb.PS

(Hautbergue et al., 2017)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, non-suppressible by Ref1^KK109076, Scer\GAL4^GMR.PF

(Hautbergue et al., 2017)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has visible | adult stage phenotype, non-suppressible by Ref1^GD4683, Scer\GAL4^GMR.PF

(Hautbergue et al., 2017)

Enhancer of

Statement

Reference

Zzzz\GGGGCC^36.UAS/Scer\GAL4^GMR.PU is an enhancer of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^GMR.PU, eRF1^GD4704

(Ortega et al., 2020)

Other

Statement

Reference

Scer\GAL4^GMR.PU, Upf1^HMC05537, Zzzz\GGGGCC^36.UAS has partially lethal - majority die phenotype

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Upf1^HMC05537, Zzzz\GGGGCC^36.UAS has majority die during P-stage phenotype

(Ortega et al., 2020)

Phenotype Manifest In

Enhanced by

Statement

Reference

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has eye phenotype, enhanceable by InR^K1409A.UAS, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, enhanceable by Art1^KK101196, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, enhanceable by Upf1^HMC05537/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, enhanceable by eRF1^GD4704/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, enhanceable by CCT8^KK100186, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, enhanceable by e(y)2^KK102036/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, enhanceable by Tnpo-SR^GD9833/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Suppressed by

Statement

Reference

Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS has autolysosome | increased number | adult stage | RU486 conditional phenotype, suppressible by Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA}

(Xu et al., 2023)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has eye phenotype, suppressible by InR^A1325D.UAS, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has eye phenotype, suppressible | partially by Akt^{T342D.S505D.GMR}, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PFa, Zzzz\GGGGCC^36.UAS has eye phenotype, suppressible | partially by Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^GMR.PFa

(Atilano et al., 2021)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, suppressible by SF2^GD12097, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, suppressible by Hsap\ETF1^UAS.cOe, Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PU, Zzzz\GGGGCC^36.UAS has eye phenotype, suppressible by Upf1^G1161/Scer\GAL4^GMR.PU

(Ortega et al., 2020)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has eye phenotype, suppressible by Hsap\MATR3^UAS.Tag:FLAG, Scer\GAL4^GMR.PF

(Ramesh et al., 2020)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has eye | adult stage phenotype, suppressible by SF2^GD12097, Scer\GAL4^GMR.PF

(Hautbergue et al., 2017)

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has eye | adult stage phenotype, non-suppressible by Ref1^KK109076, Scer\GAL4^GMR.PF

(Hautbergue et al., 2017)

Scer\GAL4^GMR.PF, Zzzz\GGGGCC^36.UAS has eye | adult stage phenotype, non-suppressible by Ref1^GD4683, Scer\GAL4^GMR.PF

(Hautbergue et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The co-expression of SF2^GD12097, but not of Ref1^KK109076 or Ref1^GD4683, fully suppresses the rough eye, fully suppresses the decreased adult locomotor activity, and partially suppresses the decreased larval locomotor activity induced by the expression of Zzzz\GGGGCC^36.Scer\UAS under the control of Scer\GAL4^GMR.PF, Scer\GAL4^da.G32, and Scer\GAL4^nSyb.PS, respectively.

The decreases in both larval and adult locomotor activity induced by the expression of Zzzz\GGGGCC^36.Scer\UAS under the control of Scer\GAL4^nSyb.PS and Scer\GAL4^da.G32, respectively, are suppressed by the co-expression of sbr^HM05135.

(Hautbergue et al., 2017)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58688

w¹¹¹⁸; P{UAS-GGGGCC.36}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

G4C2-36

(Baldwin et al., 2016)

G₄C₂-36

(Cacciottolo et al., 2019)

Zzzz\GGGGCC^36.Scer\UAS

Zzzz\GGGGCC^36.UAS

Zzzz\poly-GP^36.Scer\UAS

Zzzz\poly-GR^36.Scer\UAS

Name Synonyms

Secondary FlyBase IDs

FBal0300893
FBal0300901

References (32)

Report Sections

Open Close