FB2025_01 , released February 20, 2025
Allele: Dmel\Rab8UAS.cWa
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General Information
Symbol
Dmel\Rab8UAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0304729
Feature type
allele
Associated gene
Dmel\Rab8
Associated Insertion(s)
Carried in Construct
P{UAS-Rab8.W}
Key Links
Transgenic product class
wild_type
(West et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(West et al., 2015)
Mutagen
in vitro construct
(West et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Rab8.W}
Cytology
Description

UASt regulatory sequences drive expression of Rab8.

(West et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Rab8
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  frontotemporal dementia
      modeled by Hsap\CHMP2BIntron5.UAS
      (West et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      The synaptic overgrowth phenotype resulting from the expression of Scer\GAL4nSyb.PS>Hsap\CHMP2BIntron5.Scer\UAS is suppressed when Rab8Scer\UAS.cWa is co-expressed.

      (West et al., 2015)
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4Act5C.PI/Rab8UAS.cWa partially rescues Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4nSyb.PS/Rab8UAS.cWa partially rescues Rab81/Rab8B229

      (West et al., 2015)

      Scer\GAL4Mhc.PW/Rab8UAS.cWa partially rescues Rab81/Rab8B229

      (West et al., 2015)
      Comments

      Expression of Rab8Scer\UAS.cWa under the control of Scer\GAL4Act5C.PI and the presynaptic driver Scer\GAL4nSyb.PS is sufficient to completely rescue the increased bouton number at muscles 6/7 Rab81/Rab81 mutants.

      Postsynaptic expression of Rab8Scer\UAS.cWa under the control of Scer\GAL4Mhc.PW rescues the increased synaptic bouton number phenotype at muscle 6/7, but not synapse length at neuromuscular junctions in Rab81/Rab8B229 mutants.

      Synaptic bouton number or length in muscle 4 is not rescued by muscle expression of Rab8Scer\UAS.cWa.

      (West et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Rab8Scer\UAS.cWa
      Rab8UAS.cWa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of West
      (West et al., 2015)
      Secondary FlyBase IDs
        References (1)