FB2021_01, released Feb 18, 2021

Allele: Dmel\REPTOR-BPKO

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General Information
Symbol
Dmel\REPTOR-BPKO
Species
D. melanogaster
Name
FlyBase ID
FBal0304775
Feature type
allele
Associated gene
Dmel\REPTOR-BP
Associated Insertion(s)
TI{TI}REPTOR-BPKO
Carried in Construct
Genomic Maps
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Tiebe et al., 2015)
Mutagen
ends-out gene targeting
(Tiebe et al., 2015)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
2L:10,264,163..10,264,968 [+]
Comment:

A knockout deletion reported as mapping to R5 coordinates 2L:10 ,264,163..10,264,968.

(Tiebe et al., 2015)
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      Deletion of the 5'UTR region and the majority of the ORF of REPTOR-BP.

      (Tiebe et al., 2015)
      Insertion components
      TI{TI}REPTOR-BPKO
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants do not show strong phenotypes during larval stages under well-fed conditions: the levels of stored nutrients are not reduced, development is not delayed, size is not reduced. In contrast, mutant pupae and adults have strongly reduced TAG and glycogen levels and are extremely sensitive to starvation.

      (Tiebe et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      REPTOR-BPKO is rescued by REPTOR-BPUAS.cTa

      (Tiebe et al., 2015)
      Comments

      REPTOR-BPScer\UAS in the absence of a Scer\GAL4 driver (owing to 'leaky' transgene expression) rescues the reduced TAG levels and starvation sensitivity phenotypes of REPTOR-BPKO.

      (Tiebe et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      REPTOR-BPKO
      (Tiebe et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)