FB2025_01 , released February 20, 2025
Allele: Dmel\DnaJ-1UAS.cTa
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General Information
Symbol
Dmel\DnaJ-1UAS.cTa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Takeuchi
FlyBase ID
FBal0305147
Feature type
allele
Associated gene
Dmel\DnaJ-1
Associated Insertion(s)
Carried in Construct
P{UAS-DnaJ-1.T}
Key Links
Transgenic product class
cDNA
(Takeuchi et al., 2015)
wild_type
(Takeuchi et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Takeuchi et al., 2015)
wild_type
(Takeuchi et al., 2015)
Mutagen
in vitro construct
(Takeuchi et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-DnaJ-1.T}
Cytology
Description

UASt regulatory sequences drive expression of a DnaJ-1 cDNA (GH26396).

(Takeuchi et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
DnaJ-1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Huntington's disease
      modeled by Hsap\HTTGMR.Q120
      (Takeuchi et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of DnaJ-1Scer\UAS.cTa in photoreceptors under the control of Scer\GAL4GMR.PU suppresses the eye degeneration seen in flies expressing Hsap\HTTGMR.Q120.

      Expression of DnaJ-1Scer\UAS.cTa in the pigment cells under the control of Scer\GAL454C partially suppresses the eye degeneration seen in flies expressing Hsap\HTTGMR.Q120. There is a significant increase in the number of rhabdomeres per ommatidium compared to Hsap\HTTGMR.Q120 alone. Expression under the control of another pigment cell driver, Scer\GAL4rdhB.PW, also suppresses the degeneration, and this suppression can be canceled out by co-expressing Ykt6dsRNA.Scer\UAS.cUa.

      Expression of DnaJ-1Scer\UAS.cTa in either muscle (under the control of Scer\GAL4Mef2.PU or Scer\GAL4Mhc.PU) or fat body (using Scer\GAL4Lsp2.PH or Scer\GAL4r4) partially suppresses the photoreceptor degeneration seen in Hsap\HTTGMR.Q120 mutant flies.

      (Takeuchi et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      DnaJ-1Scer\UAS.cTa
      DnaJ-1UAS.cTa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Takeuchi
      Secondary FlyBase IDs
        References (1)