FB2025_01 , released February 20, 2025
Allele: Dmel\Arl5KO1
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General Information
Symbol
Dmel\Arl5KO1
Species
D. melanogaster
Name
FlyBase ID
FBal0314317
Feature type
allele
Associated gene
Dmel\Arl5
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Rosa-Ferreira et al., 2015)
Mutagen
Delta2-3 transposase
(Rosa-Ferreira et al., 2015)
Progenitor genotype
P{RS5}Arl55-HA-1500
(Rosa-Ferreira et al., 2015)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in deletion of the entire coding region of Arl5 including the 3' UTR and part of the 5' UTR (the 1050 base pairs 8298517-8299566 inclusive replaced by 34 base pairs of uncertain origin).

(Rosa-Ferreira et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:8,298,517..8,299,566 [-]
Comment:

A ~1 kb deletion resulting from the imprecise excision of P{RS5}Arl55-HA-1500 reported to map to 3L:8298517-8299566 in R6 coordinates. The deleted sequence is replaced by 34 bases of unknown origin.

(Rosa-Ferreira et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Arl5KO1 homozygotes appear grossly normal with no detectable defects.

      A clear enlargement of late endosomal and lysosomal structures is observed in Arl5KO1 mutant follicle cells.

      (Rosa-Ferreira et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Arl5KO1
      (Rosa-Ferreira et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)