FlyBase Allele Report: Dmel\Ire1[HMC05163]

General Information

Symbol

Dmel\Ire1^HMC05163

Species

D. melanogaster

Name

FlyBase ID

FBal0314974

Feature type

allele

Associated gene

Dmel\Ire1

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC05163}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC05163}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC05163

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^UAS.cLa.EGFP

(Li et al., 2024)

modeled by Hsap\APP^{Δ41-50.UAS.EGFP}

(Li et al., 2024)

exacerbates prion disease

modeled by Hsap\PRNP^V129.UAS.att

(Myers et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal starvation stress response | adult stage, with Scer\GAL4^αTub84B.PL

(Zhao et al., 2021)

decreased cell number | larval stage | somatic clone, with Scer\GAL4^Act.PU

(Zheng et al., 2023)

increased mortality | adult stage, with Scer\GAL4^αTub84B.PL

(Zhao et al., 2021)

Phenotype Manifest In

eye-antennal disc | somatic clone, with Scer\GAL4^Act.PU

(Zheng et al., 2023)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Ire1^HMC05163 is an enhancer of decreased cell number | larval stage | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Ire1^HMC05163, Scer\GAL4^GMR.PU is an enhancer of visible | adult stage phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

Other

Statement

Reference

Hsap\PRNP^V129.UAS, Ire1^HMC05163, Scer\GAL4^GMR.PU has decreased size | adult stage phenotype

(Myers et al., 2022)

Phenotype Manifest In

Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/Ire1^HMC05163 is an enhancer of eye-antennal disc | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Ire1^HMC05163, Scer\GAL4^GMR.PU is an enhancer of eye phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

The co-expression of Ire1^HMC05163 enhances the eye defects induced by the expression of Hsap\PRNP^V129.UAS under the control of Scer\GAL4^GMR.PU, even leading to a small eye.

(Myers et al., 2022)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

62156

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05163}attP40

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Ire1^HMC05163

ire1^RNAi-2

(Zhao et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close