FlyBase Allele Report: Dmel\htk[71]

General Information

Symbol

Dmel\htk⁷¹

Species

D. melanogaster

Name

FlyBase ID

FBal0316424

Feature type

allele

Associated gene

Dmel\htk

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sreedharan et al., 2015)

Progenitor genotype

Cytology

Description

Amino acid replacement: L982term.

(Sreedharan et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^{Q331K.UAS.cSa}

(Sreedharan et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal

(Sreedharan et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

htk⁷¹ has no effect on the Wallerian Degeneration (programmed destruction of distal severed axons) seen in wild type wing axons following axotomy.

(Sreedharan et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

htk⁷¹ is a suppressor of abnormal neuroanatomy | somatic clone phenotype of Hsap\TARDBP^UAS.cSa, Scer\GAL4^VGlut1-OK371

(Sreedharan et al., 2015)

htk⁷¹ is a suppressor | partially of abnormal neuroanatomy | somatic clone phenotype of Hsap\TARDBP^{Q331K.UAS.cSa}, Scer\GAL4^VGlut1-OK371

(Sreedharan et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

htk⁷¹ is a suppressor of leg | somatic clone phenotype of Hsap\TARDBP^UAS.cSa, Scer\GAL4^VGlut1-OK371

(Sreedharan et al., 2015)

htk⁷¹ is a suppressor of motor neuron | somatic clone phenotype of Hsap\TARDBP^UAS.cSa, Scer\GAL4^VGlut1-OK371

(Sreedharan et al., 2015)

htk⁷¹ is a suppressor of embryonic/larval neuromuscular junction | somatic clone phenotype of Hsap\TARDBP^UAS.cSa, Scer\GAL4^VGlut1-OK371

(Sreedharan et al., 2015)

htk⁷¹ is a suppressor | partially of leg | somatic clone phenotype of Hsap\TARDBP^{Q331K.UAS.cSa}, Scer\GAL4^VGlut1-OK371

(Sreedharan et al., 2015)

htk⁷¹ is a suppressor | partially of motor neuron | somatic clone phenotype of Hsap\TARDBP^{Q331K.UAS.cSa}, Scer\GAL4^VGlut1-OK371

(Sreedharan et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

htk⁷¹ partially suppresses the degeneration seen in leg motor neuron clones expressing Hsap\TARDBP^{Q331K.Scer\UAS.cSa} under the control of Scer\GAL4^VGlut-OK371. This suppression is reversed in the presence of Dp(1;3)DC353.

htk⁷¹ suppresses the degeneration seen in leg motor neuron clones expressing Hsap\TARDBP^Scer\UAS.cSa under the control of Scer\GAL4^VGlut-OK371.

(Sreedharan et al., 2015)

Complementation and Rescue Data

Fails to complement

htk³⁹

(Sreedharan et al., 2015)

htk⁴⁷

(Sreedharan et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

htk⁷¹

(Singh et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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