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General Information
Symbol
Dmel\Neurl4Δ1
Species
D. melanogaster
Name
FlyBase ID
FBal0316516
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of P{EPgy2}Neurl4EY12221. A small portion of the P-element remains.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Neurl4Δ1 mutants display a dominant misshapen primordial germ cells (PGC) in well over half of the embryos from heterozygous mothers. The frequency of PGC defects is similar in progeny embryos of Neurl4Δ1/+ females crossed with either Neurl4Δ1 or wild-type males, demonstrating that the PGC phenotype is independent of zygotic genotype. Embryos from wild-type females crossed to homozygous Neurl4Δ1 males do not shot the PGC phenotype.

Embryos from Neurl4Δ1 mutant mothers show multiple PGC defects at stage 10 during migration: the protrusion on PGCs are often smaller than normal; there are displaced vesicles just as seen in stage 5 embryos; and some PGCs are elongated relative to those in wild-type embryos.

Neither wild-type nor Neurl4Δ1/+ mutant stage 5 embryos PGCs are positive for a marker of apoptosis.

Homozygous or hemizygous mutants are viable and appear healthy. However, a fraction of the progeny of Neurl4Δ1 mutant mothers are agametic and thus infertile. Examination of embryos from Neurl4Δ1 mutant mothers reveals that, in addition to the abnormal PGC morphology, the number of PGCs is reduced compared with wild-type.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments

Expression of Neurl4+t7.9 fully rescues the primordial germ cell phenotype of Neurl4Δ1/+.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)