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General Information
Symbol
Dmel\esgL4
Species
D. melanogaster
Name
FlyBase ID
FBal0316540
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
transposable element insertion site
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference
A P{GawB} element has been inserted 39 nucleotides downstream of the esg transcription initiation site ( 2L:15333866 - R6).
Insertion components
P{GawB}esgL4
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Heterozygous esgL4 mutant flies exhibit increased sensitivity to nicotine. Approximately 8% of heterozygous esgL4 flies exhibit cuticle defects such as loss of bristles in the tergites and sternites, and loss of pigmentation in the dorsal abdomen. Responses to heat and ether are normal. Expression of esgHMS00025 under the control of Scer\GAL4L4 enhances the cuticle phenotypes seen in heterozygous esgL4 mutant flies from 8% to 100%. The resulting flies are not viable.
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Suppressed by
Other
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Expression of P{UAS-mir-310.cluster.DsRed} (which consists of the mir-310Scer\UAS.cluster, mir-311Scer\UAS.cluster, mir-312Scer\UAS.cluster and mir-313Scer\UAS.cluster alleles) under the control of Scer\GAL4L4 enhances the cuticle phenotype seen in esgL4 mutant flies, with 100% of the resulting flies having phenotype compared to 8% in esgL4/+. Only 14% of the flies are viable compared with 100% in esgL4/+. The increased nicotine sensitivity is also enhanced. Expression of mir-311Scer\UAS.T:Ppyr\LUC under the control of Scer\GAL4L4 enhances the cuticle phenotype seen in esgL4/+ mutant flies, with 23% of the resulting flies having phenotypes compared with 8% in esgL4/+ alone. Viability is unaffected. The increase in nicotine sensitivity is also enhanced. Expression of mir-14Scer\UAS.T:Ppyr\LUC under the control of Scer\GAL4L4 suppresses the cuticle phenotype and nicotine sensitivity seen in esgL4 mutant flies. Viability is unaffected. One copy each of P{GawB}mir-310L70 (comprised of mir-310L70, mir-311L70 and mir-312L70) and esgL4 results in increased sensitivity to nicotine compared to esgL4/+ alone.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Rescued by
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
esgL4
Name Synonyms
Secondary FlyBase IDs
    References (1)