mutant flies exhibit increased sensitivity to nicotine. Approximately 8% of heterozygous esgL4
flies exhibit cuticle defects such as loss of bristles in the tergites and sternites, and loss of pigmentation in the dorsal abdomen. Responses to heat and ether are normal.
Expression of esgHMS00025
under the control of Scer\GAL4L4
enhances the cuticle phenotypes seen in heterozygous esgL4
mutant flies from 8% to 100%. The resulting flies are not viable.