FlyBase Allele Report: Dmel\yki[UAS.cUa]

General Information

Symbol

Dmel\yki^UAS.cUa

Species

D. melanogaster

Name

FlyBase ID

FBal0316876

Feature type

allele

Associated gene

Dmel\yki

Associated Insertion(s)

Carried in Construct

P{UAS-yki.U}

Also Known As

UAS-yki, UAS.Yki

Key Links

Transgenic product class

wild_type

(Barrios et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Barrios et al., 2015)

Mutagen

in vitro construct

(Barrios et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-yki.U}

Cytology

Description

UAS regulatory sequences drive expression of yki.

(Barrios et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

yki

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with RhoBTB^HMC03199

(Nguyen et al., 2020)

CEA with RhoBTB^VSH330130

(Nguyen et al., 2020)

CEA with Lkb1^KK108675

(Nguyen et al., 2020)

CEA with Lkb1^HMS01351

(Nguyen et al., 2020)

CEA with Lkb1^GL00019

(Nguyen et al., 2020)

CEA with Lkb1^VSH330167

(Nguyen et al., 2020)

CEA

(Guo et al., 2020)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates peroxisome biogenesis disorder 2A

modeled by Pex5^GD14972

(Pinelli et al., 2024)

model of cancer

is ameliorated by Rox8^EY02351

(Guo et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage, with Scer\GAL4^ptc.PU

(Guo et al., 2020)

increased size | adult stage, with Scer\GAL4^GMR.PU

(Guo et al., 2020)

increased size | adult stage, with Scer\GAL4^ptc.PU

(Li et al., 2024, Guo et al., 2020)

increased size | third instar larval stage, with Scer\GAL4^ptc.PU

(Guo et al., 2020)

visible | adult stage, with Scer\GAL4^GMR.PU

(Guo et al., 2020)

visible | adult stage, with Scer\GAL4^ptc.PU

(Li et al., 2024, Guo et al., 2020)

Phenotype Manifest In

adult gut, with Scer\GAL4^mex1.2.1

(Pinelli et al., 2024)

anterior-posterior compartment boundary of the wing disc, with Scer\GAL4^ptc.PU

(Guo et al., 2020)

eye, with Scer\GAL4^GMR.PU

(Guo et al., 2020)

eye, with Scer\GAL4^salm.EPv

(Barrios et al., 2015)

first basal wing cell, with Scer\GAL4^ptc.PU

(Guo et al., 2020)

wing, with Scer\GAL4^ptc.PU

(Li et al., 2024)

Detailed Description

Statement

Reference

Expressing yki^UAS.cUa under the control of Scer\GAL4^ptc.PU results in tissue overgrowth along the third instar wing disc anterior-posterior compartment boundary and in an increased area between L3 and L4 in the wing.

Expression under the control of Scer\GAL4^GMR.PU leads to an enlarged eye.

(Guo et al., 2020)

Expression of yki^Scer\UAS.cUa under the control of Scer\GAL4^salm.EPv results in eye disc overgrowth.

(Barrios et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^ptc.PU, yki^UAS.cUa has increased size | third instar larval stage phenotype, suppressible | partially by Rox8^EY02351, Scer\GAL4^ptc.PU

(Guo et al., 2020)

Scer\GAL4^GMR.PU, yki^UAS.cUa has increased size | adult stage phenotype, suppressible | partially by Rox8^EY02351, Scer\GAL4^GMR.PU

(Guo et al., 2020)

Scer\GAL4^GMR.PU, yki^UAS.cUa has visible | adult stage phenotype, suppressible | partially by Rox8^EY02351, Scer\GAL4^GMR.PU

(Guo et al., 2020)

Scer\GAL4^ptc.PU, yki^UAS.cUa has visible | adult stage phenotype, suppressible by Rox8^EY02351, Scer\GAL4^ptc.PU

(Guo et al., 2020)

Scer\GAL4^ptc.PU, yki^UAS.cUa has increased size | adult stage phenotype, suppressible by Rox8^EY02351, Scer\GAL4^ptc.PU

(Guo et al., 2020)

Suppressor of

Statement

Reference

yki^UAS.cUa/Scer\GAL4^ptc.PU is a suppressor of decreased size | adult stage phenotype of Scer\GAL4^ptc.PU, TER94^{AA.UAS.cLa.Tag:V5}

(Li et al., 2024)

yki^UAS.cUa, Scer\GAL4^mex1.2.1 is a suppressor of decreased cell size | adult stage phenotype of Pex5^GD14972, Scer\GAL4^mex1.2.1

(Pinelli et al., 2024)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, yki^UAS.cUa has eye phenotype, suppressible | partially by Rox8^EY02351, Scer\GAL4^GMR.PU

(Guo et al., 2020)

Scer\GAL4^ptc.PU, yki^UAS.cUa has first basal wing cell phenotype, suppressible by Rox8^EY02351, Scer\GAL4^ptc.PU

(Guo et al., 2020)

Scer\GAL4^ptc.PU, yki^UAS.cUa has anterior-posterior compartment boundary of the wing disc phenotype, suppressible | partially by Rox8^EY02351, Scer\GAL4^ptc.PU

(Guo et al., 2020)

Scer\GAL4^salm.EPv, yki^UAS.cUa has eye phenotype, suppressible by Scer\GAL4^salm.EPv/caup^UAS.Tag:HA

(Barrios et al., 2015)

Suppressor of

Statement

Reference

yki^UAS.cUa/Scer\GAL4^ptc.PU is a suppressor of wing phenotype of Scer\GAL4^ptc.PU, TER94^{AA.UAS.cLa.Tag:V5}

(Li et al., 2024)

yki^UAS.cUa, Scer\GAL4^mex1.2.1 is a suppressor of adult midgut phenotype of Pex5^GD14972, Scer\GAL4^mex1.2.1

(Pinelli et al., 2024)

yki^UAS.cUa, Scer\GAL4^mex1.2.1 is a suppressor of adult enterocyte phenotype of Pex5^GD14972, Scer\GAL4^mex1.2.1

(Pinelli et al., 2024)

yki^UAS.cUa, Scer\GAL4^mex1.2.1 is a suppressor of adult gut phenotype of Pex5^GD14972, Scer\GAL4^mex1.2.1

(Pinelli et al., 2024)

Other

Statement

Reference

CycE^UAS.cLa, Scer\GAL4^salm.EPv, caup^UAS.Tag:HA, yki^UAS.cUa has eye phenotype

(Barrios et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of caup^{Scer\UAS.T:Ivir\HA1} suppresses the eye disc overgrowth seen when yki^Scer\UAS.cUa is expressed under the control of Scer\GAL4^salm.EPv. This suppression is partially reverted upon co-expression of CycE^Scer\UAS.cLa.

(Barrios et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

yki^Scer\UAS.cUa

yki^UAS.cUa

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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