FB2025_01 , released February 20, 2025
Allele: Dmel\dpnUAS.cUa
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General Information
Symbol
Dmel\dpnUAS.cUa
Species
D. melanogaster
Name
FlyBase ID
FBal0316893
Feature type
allele
Associated gene
Dmel\dpn
Associated Insertion(s)
Carried in Construct
P{UAS-dpn.U}
Also Known As
UAS-dpn
Key Links
Transgenic product class
wild_type
(To et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(To et al., 2015)
Mutagen
in vitro construct
(To et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-dpn.U}
Cytology
Description

UAS regulatory sequences drive expression of dpn.

(To et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dpn
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  brain cancer
      CEA
      (Morrissy et al., 2016)
      model of  central nervous system cancer
      CEA
      (Francisco et al., 2020)
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  brain cancer
      is ameliorated by p53DN.UAS.cUa
      (Morrissy et al., 2016)
      model of  central nervous system cancer
      is ameliorated by ClicEY04209
      (Francisco et al., 2020)
      is ameliorated by ClicG0472
      (Francisco et al., 2020)
      is ameliorated by ClicKK101604
      (Francisco et al., 2020)
      is ameliorated by eagGD3363
      (Francisco et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The apoptosis rate at 36 hours after larval hatching (ALH) in the brains of flies expressing dpnScer\UAS.cUa under the control of Scer\GAL4insc-Mz1407 is significantly higher than in wild type. From 48h ALH onwards it is significantly lower than in wild type, and the brain displays excessive growth. Between 24 and 36 hours the cell growth rate is higher than in controls. Unlike in wild type brains, in which apoptosis is limited to the dorsal-medial region of the brain lobes, the apoptosis in brains expressing dpnScer\UAS.cUa is more randomly distributed at 72 hours ALH.

      (To et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      dpnScer\UAS.cUa
      dpnUAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (4)