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General Information
Symbol
Dmel\Gr98b1
Species
D. melanogaster
Name
FlyBase ID
FBal0317406
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The N-terminal 233 out of 403 amino acids have been deleted from Gr98b.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Gr98b1 mutant flies do not show significant changes in the expected avoidance response to food laced with acetic acid (5%), as compared to controls.

Gr98b1 mutant flies show reduced L-canavanine avoidance in a two-way choice behavioral assay compared with wild type flies. L-canavanine-induced action potentials are also abolished. Gr98b1 mutant flies display robust aversion and electrophysiological responses to papaverine, strychnine, denatonium, berberine, lobeline, caffeine, N,N-diethyl-m-toluamide (DEET) and quinine.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Gr98bScer\UAS.cSa under the control of any of Scer\GAL4Gr66a.PD, Scer\GAL4Gr8a.0.7 or Scer\GAL4Gr98b.8.9 rescues the L-canavanine avoidance defects seen in Gr98b1 mutant flies. The loss of L-canavanine-induced action potentials is rescued when Gr98bScer\UAS.cSa is expressed under the control of Scer\GAL4Gr66a.PD.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (6)