FB2021_01, released Feb 18, 2021

Allele: Dmel\Gr98b1

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General Information
Symbol
Dmel\Gr98b1
Species
D. melanogaster
Name
FlyBase ID
FBal0317406
Feature type
allele
Associated gene
Dmel\Gr98b
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ends-out gene targeting
(Shim et al., 2015)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Cytology
      Nature of the lesion
      Statement
      Reference

      The N-terminal 233 out of 403 amino acids have been deleted from Gr98b.

      (Shim et al., 2015)
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Gr98b1 mutant flies do not show significant changes in the expected avoidance response to food laced with acetic acid (5%), as compared to controls.

      (Rimal et al., 2019)

      Gr98b1 mutant flies show reduced L-canavanine avoidance in a two-way choice behavioral assay compared with wild type flies. L-canavanine-induced action potentials are also abolished. Gr98b1 mutant flies display robust aversion and electrophysiological responses to papaverine, strychnine, denatonium, berberine, lobeline, caffeine, N,N-diethyl-m-toluamide (DEET) and quinine.

      (Shim et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Gr98b1 is rescued by Scer\GAL4Gr66a.PD/Gr98bUAS.cSa

      (Shim et al., 2015)

      Gr98b1 is rescued by Scer\GAL4Gr8a.0.7/Gr98bUAS.cSa

      (Shim et al., 2015)

      Gr98b1 is rescued by Gr98bUAS.cSa/Scer\GAL4Gr98b.8.9

      (Shim et al., 2015)
      Comments

      Expression of Gr98bScer\UAS.cSa under the control of any of Scer\GAL4Gr66a.PD, Scer\GAL4Gr8a.0.7 or Scer\GAL4Gr98b.8.9 rescues the L-canavanine avoidance defects seen in Gr98b1 mutant flies. The loss of L-canavanine-induced action potentials is rescued when Gr98bScer\UAS.cSa is expressed under the control of Scer\GAL4Gr66a.PD.

      (Shim et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Gr98b1
      (Rimal and Lee, 2019, Rimal et al., 2019, Sang et al., 2019, Lee et al., 2018, Poudel et al., 2017, Shim et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)