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General Information
Symbol
Dmel\Pten5
Species
D. melanogaster
Name
FlyBase ID
FBal0318138
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A10258825G

Reported nucleotide change:

A509G

Amino acid change:

D170G | Pten-PA; D170G | Pten-PB; D170G | Pten-PC; D170G | Pten-PD; D170G | Pten-PE; D170G | Pten-PG; D170G | Pten-PH

Reported amino acid change:

D170G

Comment:

Position of mutation on genomic sequence inferred by FlyBase curator from the reported nucleic acid and amino acid changes.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

A single A to G (GAC to GGC) point mutation was identified at position 509 of the Pten open reading frame, which causes an aspartate (Asp) to glycine (Gly) substitution at position 170 of the Pten polypeptide.

Amino acid replacement: D170G.

Nucleotide substitution: A509G.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies trans-heterozygous for Pten5 and Df(2L)flp170B have eyes with a slightly disorganised ommatidial array.

Homozygous Pten5 flies also display a rough eye phenotype.

Pten5/Pten1 flies exhibit a highly penetrant, but mild, disorganised eye phenotype at the posterior edge in the midline.

Pten5/Ptendj189 flies exhibit a highly penetrant, but mild, disorganised eye phenotype at the posterior edge in the midline.

Transheterozygous mutant Pten5/Pten1 males have significantly (~20%) greater body mass than wild-type.

A small proportion of newly eclosed Pten5/Pten1 flies display outstretched and paralysed wing phenotype. The flies are unable to fly. The proportion of flightless mutant increases as flies age.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference

Pten1/Pten5 has flightless | progressive phenotype, suppressible | partially by Rheb[+]/RhebAV4

Pten1/Pten5 has flightless | progressive phenotype, suppressible | partially by Tor[+]/TorΔP

Pten3/Pten5 has flightless phenotype, suppressible | partially by Akt1[+]/Akt11

Ptendj189/Pten5 has flightless phenotype, suppressible | partially by Akt1[+]/Akt13

Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

Pten1/Pten5 is partially rescued by Pten+t6

Ptendj189/Pten5 is partially rescued by Pten+t6

Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)