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General Information
Symbol
Dmel\Hsc70-4D10N.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0318415
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Genomic fragment encoding a mutated form of Hsc70-4 which lacks chaperone activity (contains the amino acid replacement D10N which removes ATPase activity), expressed under its endogenous promoter. A Tag:HA tag has been inserted at the N-terminal end of the Hsc70-4 coding sequence.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Hsc70-4D10N.T:Ivir\HA1 completely rescues the decrease in endosomal microautophagy which is seen at the neuromuscular junction in Hsc70-4Δ19/Df(3R)BSC471 larvae.

Expression of Hsc70-4D10N.T:Ivir\HA1 does not rescue the decrease in mean excitatory junctional current amplitude which is seen at the neuromuscular junction in Hsc70-4Δ19/Df(3R)BSC471 larvae.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Hsc70-4D10N.T:Ivir\HA1
Hsc70-4D10N.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (1)