FB2025_01 , released February 20, 2025
Allele: Dmel\gigUAS.cUa
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General Information
Symbol
Dmel\gigUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0318720
Feature type
allele
Associated gene
Dmel\gig
Associated Insertion(s)
Carried in Construct
P{UAS-gig.U}
Also Known As
UAS-TSC2
Key Links
Transgenic product class
wild_type
(Koyama and Mirth, 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Koyama and Mirth, 2016)
Mutagen
in vitro construct
(Koyama and Mirth, 2016)
Progenitor genotype
Carried in construct
P{UAS-gig.U}
Cytology
Description

UAS regulates expression of gig.

(Koyama and Mirth, 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
gig
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of gigUAS.cUa under the control of Scer\GAL4GSG5966 (and RU486 feeding) induces lipid droplet autophagy (dual LS2- and Atg8-positive puncta) in the adult midgut, as compared to controls.

      (Lee et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of Tsc1Scer\UAS.cUa and gigScer\UAS.cUa driven by Scer\GAL4C7 significantly decreases male and female body size (body weight measured at pharate adult stage), significantly decreases larval growth rates and significantly increases the duration of the third instar larval stage.

      At 22[o]C, co-expression of Gbp1Scer\UAS.cKa or Gbp2Scer\UAS.cKa partially suppresses the body size decreases, slower larval growth rate, and increased duration of the third instar larval stage (L3) seen in animals with Tsc1Scer\UAS.cUa and gigScer\UAS.cUa driven by Scer\GAL4C7 (though body size, larval growth rate and duration of L3 is still significantly reduced compared to wild type).

      (Koyama and Mirth, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      gigScer\UAS.cUa
      gigUAS.cUa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Unknown
      Secondary FlyBase IDs
        References (9)