FB2025_05 , released December 11, 2025
Allele: Dmel\icsRNAi.UAS.WIZ
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General Information
Symbol
Dmel\icsRNAi.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0318753
Feature type
allele
Associated gene
Dmel\ics
Associated Insertion(s)
Carried in Construct
P{UAS-ics.RNAi.WIZ}
Key Links
Transgenic product class
RNAi_reagent
(Ojelade et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Ojelade et al., 2015)
Mutagen
in vitro construct
(Ojelade et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-ics.RNAi.WIZ}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat targeting the fourth exon of ics.

(Ojelade et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
ics
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  alcohol use disorder
      CEA
      (Ojelade et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies with expression of icsdsRNA.Scer\UAS.WIZ driven by Scer\GAL4elav.PU are more resistant to ethanol-induced sedation than controls.

      Adult mushroom body specific (using Scer\GAL4Mef2.247.Switch adults fed mifepristone/RU486) icsdsRNA.Scer\UAS.WIZ knockdown causes loss of acquired ethanol preference, as is seen in wild type (show increased ethanol consumption over 4 days); mutant flies have normal naive ethanol preference.

      (Ojelade et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ilk1/+ or stck3R-17/+ significantly suppresses (to wild type levels) the increased resistance to ethanol-induced sedation seen in flies with expression of icsdsRNA.Scer\UAS.WIZ driven by Scer\GAL4elav.PU.

      (Ojelade et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      icsRNAi.UAS.WIZ
      icsdsRNA.Scer\UAS.WIZ
      icsdsRNA.UAS.WIZ
      Name Synonyms
      Secondary FlyBase IDs
        References (2)