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General Information
Symbol
Dmel\Arl2Q70L.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0318770
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulates expression of Arl2 full-length coding sequence containing a Q70L mutation, thus generating a constitutively active GTP-bound form of Arl2.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of Arl2Q70L.Scer\UAS driven by Scer\GAL4insc.PU leads to dramatic depletion of neuroblasts in third instar larval central brains; overexpression in both type I (Scer\GAL4ase.neuro) and II (Scer\GAL4wor.PA and Scer\GAL80ase.PN) neuroblast lineages leads to neuroblast depletion.

Overexpression of Arl2Q70L.Scer\UAS driven by Scer\GAL4insc.PU leads to more abundant microtubules in interphase neuroblasts compared to controls and around half of Arl2Q70L.Scer\UAS neuroblasts form monopolar spindles; in a microtubule regrowth assay (after ice treatment), the majority of metaphase neuroblasts show more abundant microtubules emanating from centrosomes and distance between centrosomes is increased, compared to controls. After 2min recovery after ice treatment, most mutant metaphase centrosomes contain only one large centrosome.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Arl2Q70L.Scer\UAS
Arl2Q70L.UAS
Name Synonyms
Secondary FlyBase IDs
    References (1)