Open Close
General Information
Symbol
Dmel\FrlEx83
Species
D. melanogaster
Name
FlyBase ID
FBal0318778
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Remobilizaton of the isogenized P{XP}Frld06832 progenitor (after recombining away a second site lethal). The resulting deletion retains some scrambled P-element sequences (including some UAS sequences) at the original 5' P end in intron 1 of Frl, but deletes the Frl start codon. The upstream breakpoint is in Hsc70Cb and deletes a total of 21.4 kb.

Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

FrlEx83/FrlEx83 clones (in a Minute background) have weak ommatidial rotation defects (planar cell polarity-like defects) in the adult eye. 14% of FrlEx83/FrlEx83 mutant mushroom body clones show premature axon growth arrest (but not bifurcation/guidance defects).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhanced by
NOT suppressed by
Enhancer of
Statement
Reference

Frl[+]/FrlEx83 is an enhancer of abnormal neuroanatomy | adult stage phenotype of DAAMEx1

Frl[+]/FrlEx83 is an enhancer of abnormal neuroanatomy | adult stage phenotype of Cdc422

Frl[+]/FrlEx83 is an enhancer of abnormal neuroanatomy | adult stage phenotype of DAAMEx4

NOT Enhancer of
Statement
Reference

Frl[+]/FrlEx83 is a non-enhancer of abnormal planar polarity | adult stage phenotype of dsh1

Frl[+]/FrlEx83 is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of dsh1

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

Frl[+]/FrlEx83 is a non-suppressor of abnormal planar polarity | adult stage phenotype of dsh1

Other
Phenotype Manifest In
NOT Enhanced by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Statement
Reference

Frl[+]/FrlEx83 is an enhancer of axon | adult stage phenotype of DAAMEx1

Frl[+]/FrlEx83 is an enhancer of axon | adult stage phenotype of DAAMEx4

Frl[+]/FrlEx83 is an enhancer of axon | adult stage phenotype of Cdc422

NOT Enhancer of
Statement
Reference

Frl[+]/FrlEx83 is a non-enhancer of ommatidium phenotype of dsh1

Frl[+]/FrlEx83 is a non-enhancer of axon | adult stage phenotype of dsh1

Frl[+]/FrlEx83 is a non-enhancer of adult mushroom body alpha-lobe | adult stage phenotype of dsh1

Frl[+]/FrlEx83 is a non-enhancer of adult mushroom body beta-lobe | adult stage phenotype of dsh1

Frl[+]/FrlEx83 is a non-enhancer of ommatidium phenotype of Rac1V12.UAS, Scer\GAL4hs.2sev

Suppressor of
Statement
Reference
NOT Suppressor of
Statement
Reference

Frl[+]/FrlEx83 is a non-suppressor of ommatidium phenotype of dsh1

Other
Additional Comments
Genetic Interactions
Statement
Reference

R-cell loss in flies with Cdc42Scer\UAS.cWa driven by Scer\GAL4sev.EP is partially (but significantly) suppressible in the presence of FrlEx83/+.

Presence of FrlEx83/+ does not enhance eye phenotypes in flies with Rac1V12.Scer\UAS driven by Scer\GAL4hs.2sev.

Presence of FrlEx83/+ does not significantly alter eye phenotypes seen in dsh1/Y flies. Presence of dsh1/Y (or dsh1/+ females) does not significantly alter eye phenotypes in FrlEx83/FrlEx83 clones.

DAAMEx68/DAAMEx68; FrlEx83/FrlEx83 double mutant eye R-cell clones lack rhabdomere-associated pigment granules and double mutant R-cells show a partially penetrant cell autonomous small rhabdomere phenotype (compared to DAAMEx68/DAAMEx68 mutants).

Presence of FrlEx83/+ enhances axon growth phenotypes seen in the mushroom body of DAAMEx4/Y or Cdc422/Y (but not dsh1/Y) males.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Frl+tFlyFOS-023275 rescues ommatidial rotation defects in FrlEx83/FrlEx83 somatic clones (in a Minute background), and rescues lethality of homozygous mutants.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
FrlEx83
Name Synonyms
Secondary FlyBase IDs
    References (1)