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General Information
Symbol
Dmel\Rtnl1UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0318878
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the Rtnl1-PB isoform (cDNA clone LD14068), which is tagged with Tag:HA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Overexpression of Rtnl1Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4Toll-6-D42 leads to significant decreases in excitatory junction potential (EJP) amplitude (at 0.1 mM Ca[2+], accompanied by a significant decrease in frequency of synaptic transmission successes); corrected quantal content at 1.5 mM Ca[2+] does not significantly decrease compared to controls at the neuromuscular junction of third instar larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Rtnl1Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4arm.PS significantly partially rescues decreased EJP amplitude at the NMJ of Rtnl11.W/Rtnl11.W third instar larvae; expression driven by Scer\GAL4da.G32 fully rescues EJP amplitude (and frequency of synaptic successes). Expression of Rtnl1Scer\UAS.T:Ivir\HA1 driven by Scer\GAL4Toll-6-D42 or Scer\GAL4Mef2.PR fails to rescue decreases in EJP amplitude (and frequency of synaptic successes) at the NMJ of Rtnl11.W/Rtnl11.W third instar larvae. Expression of Rtnl1Scer\UAS.T:Ivir\HA1 driven simultaneously by Scer\GAL4VGlut-OK371, Scer\GAL4Mef2.PR and Scer\GAL4Gli.PU rescues decreases in EJP amplitude (and frequency of synaptic successes) at the NMJ of Rtnl11.W/Rtnl11.W third instar larvae.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Rtnl1Scer\UAS.T:Ivir\HA1
Rtnl1UAS.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (2)