Open Close
General Information
Symbol
Dmel\Urm1n123
Species
D. melanogaster
Name
FlyBase ID
FBal0319058
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Inferred boundaries of a 620 bp deletion resulting from the imprecise excision of P{SUPor-P}Urm1KG08138 which extends from the site of the insertion into the Urm1 coding sequence and removes the CDS.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

620bp deletion removing the entire Urm1 locus. Generated by imprecise excision of P{SUPor-P}Urm1KG08138.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

20% of Urm1n123/Urm1n123 animals die during embryogenesis and 60% die at late pupal stages (compared to revertant controls); mutant escapers (primarily females, after a small but significant delay in development) have a significantly reduced lifespan, are smaller, less active, and have reduced fecundity compared to controls.

Urm1n123/Urm1n123 flies survive longer than controls under exposure to oxidative stress (10mM paraquat).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Df(2L)Exel7038/+ or Df(2L)BSC215/+ enhances lethality in Urm1n123/Urm1n123.

Prx5EY02106/Prx5EY02106 does not significantly alter survival rates of Urm1n123/Urm1n123 flies under oxidative stress, with double mutants surviving significantly longer than wild type or Prx5EY02106/Prx5EY02106 flies.

Jafrac1KG05372/Jafrac1KG05372 significantly suppresses the resistance to oxidative stress (increased survival under 10mM paraquat conditions) seen in Urm1n123/Urm1n123 flies.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Urm1Scer\UAS.cKa (but not Urm1ΔGG.Scer\UAS) driven ubiquitously by Scer\GAL4Act5C.PU rescues lethality in Urm1n123/Urm1n123 animals; indeed, expression of Urm1ΔGG.Scer\UAS increases lethality. Expression of Urm1Scer\UAS.T:Zzzz\FLAG driven ubiquitously by Scer\GAL4Act5C.PU reduces the increase in resistance to oxidative stress seen in Urm1n123/Urm1n123 flies to control levels.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)