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General Information
Symbol
Dmel\ktubmutB.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0319127
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a mutated form of ktub; sequence in the putative phosphoinositide-binding domain is changed from K292LR to A292LA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

INPP5EMI02221/INPP5EMI02221 ktub1/ktub1 flies with expression of ktubScer\UAS.cPa or ktubmutB.Scer\UAS driven by Scer\GAL4nan.PK show significantly reduced amplitude of sound-evoked potentials from antennal nerves compared to ktub1/ktub1 Scer\GAL4nan.PK>ktubScer\UAS.cPa flies (similar to wild type amplitude); however, INPP5EMI02221/INPP5EMI02221 ktub1/ktub1 flies with expression of ktubmutB.Scer\UAS have a significantly increased amplitude in comparison to those with expression of ktubScer\UAS.cPa.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Fails to rescue
Comments

Expression of ktubScer\UAS.cPa (but not ktubmutB.Scer\UAS) driven by Scer\GAL4nan.PK leads to amplitude of sound-evoked potentials from ktub1/ktub1 antennal nerves being similar to controls.

Expression of ktubmutB.Scer\UAS driven by Scer\GAL4nan.PK partially rescues auditory defects in ktub1/ktub1 flies.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ktubmutB.Scer\UAS
ktubmutB.UAS
Name Synonyms
Secondary FlyBase IDs
    References (2)