FlyBase Allele Report: Dmel\Clbn[UAS.cWa]

General Information

Symbol

Dmel\Clbn^UAS.cWa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Wang

FlyBase ID

FBal0319137

Feature type

allele

Associated gene

Dmel\Clbn

Associated Insertion(s)

Carried in Construct

P{UAS-Clbn.W}

Also Known As

UAS-clbn

Allele class

Mutagen

in vitro construct - regulatory fusion

Nature of the Allele

Allele class

Mutagen

in vitro construct - regulatory fusion

(Wang et al., 2013)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Carried in construct

P{UAS-Clbn.W}

Cytology

Nature of the lesion

Statement

Reference

UAS regulatory sequences drive expression of a Clbn cDNA.

(Wang et al., 2013)

Allele components

Product class / Tool use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Clbn

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

increased cell death | third instar larval stage, with Scer\GAL4^GMR.PU

(Wang et al., 2013)

visible, with Scer\GAL4^GMR.PU

(Wang et al., 2013)

Phenotype Manifest In

eye, with Scer\GAL4^GMR.PU

(Wang et al., 2013)

eye disc | third instar larval stage, with Scer\GAL4^GMR.PU

(Wang et al., 2013)

ommatidium, with Scer\GAL4^GMR.PU

(Wang et al., 2013)

Detailed Description

Statement

Reference

Expression of Clbn^Scer\UAS.cWa driven by Scer\GAL4^GMR.PU induces apoptosis in imaginal eye discs of third instar larvae. Expression of Clbn^Scer\UAS.cWa driven by Scer\GAL4^GMR.PU causes mild (more extreme with expression of two copies) rough eye phenotypes in adults; ommatidia are disrupted.

(Wang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Clbn^UAS.cWa, Scer\GAL4^GMR.PU has visible phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Wang et al., 2013)

Clbn^UAS.cWa, Scer\GAL4^GMR.PU has increased cell death | third instar larval stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Wang et al., 2013)

Clbn^UAS.cWa has increased cell death | third instar larval stage phenotype, suppressible by hid⁰⁵⁰¹⁴

(Wang et al., 2013)

Phenotype Manifest In

Suppressed by

Statement

Reference

Clbn^UAS.cWa, Scer\GAL4^GMR.PU has eye phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Wang et al., 2013)

Clbn^UAS.cWa, Scer\GAL4^GMR.PU has ommatidium phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Wang et al., 2013)

Clbn^UAS.cWa, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible by BacA\p35^UAS.cHa, Scer\GAL4^GMR.PU

(Wang et al., 2013)

Clbn^UAS.cWa, Scer\GAL4^GMR.PU has eye disc | third instar larval stage phenotype, suppressible by hid⁰⁵⁰¹⁴

(Wang et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

hid⁰⁵⁰¹⁴ suppresses the induction of apoptosis seen in third instar eye discs with expression of Clbn^Scer\UAS.cWa driven by Scer\GAL4^GMR.PU.

(Wang et al., 2013)

Xenogenetic Interactions

Statement

Reference

Co-expression of BacA\p35^Scer\UAS.cHa suppresses adult eye phenotypes and apoptosis in third instar eye discs in Scer\GAL4^GMR.PU>Clbn^Scer\UAS.cWa animals.

(Wang et al., 2013)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Clbn^Scer\UAS.cWa

Clbn^UAS.cWa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Wang

Secondary FlyBase IDs

References (3)

Report Sections

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