FlyBase Allele Report: Dmel\SCCRO[DAD.UAS]

General Information

Symbol

Dmel\SCCRO^DAD.UAS

Species

D. melanogaster

Name

FlyBase ID

FBal0319334

Feature type

allele

Associated gene

Dmel\SCCRO

Associated Insertion(s)

Carried in Construct

P{UAS-SCCRO.DAD}

Key Links

Transgenic product class

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

Mutagen

in vitro construct

(Fu et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-SCCRO.DAD}

Cytology

Description

UAS regulatory sequences drive expression of a mutated form of SCCRO which is deficient in neddylation activity (carries mutations in the DAD patch).

(Fu et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

SCCRO

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Over-expression of SCCRO^DAD.Scer\UAS driven by Scer\GAL4^GMR.PF does not significantly affect eye morphology; expression driven by Scer\GAL4^ptc.PU does not significantly affect cell size or number in the wing blade.

(Fu et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

SCCRO^DAD.UAS, Scer\GAL4^GMR.PF is a non-suppressor of visible phenotype of SCCRO4^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Fu et al., 2016)

SCCRO^DAD.UAS/Scer\GAL4^GMR.PF is a non-suppressor of decreased cell number | adult stage phenotype of SCCRO4^UAS.Tag:MYC, Scer\GAL4^ptc.PU

(Fu et al., 2016)

SCCRO^DAD.UAS/Scer\GAL4^GMR.PF is a non-suppressor of decreased cell size | adult stage phenotype of SCCRO4^UAS.Tag:MYC, Scer\GAL4^ptc.PU

(Fu et al., 2016)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

SCCRO^DAD.UAS, Scer\GAL4^GMR.PF is a non-suppressor of eye phenotype of SCCRO4^UAS.Tag:MYC, Scer\GAL4^GMR.PF

(Fu et al., 2016)

SCCRO^DAD.UAS/Scer\GAL4^GMR.PF is a non-suppressor of anterior-posterior compartment boundary of the wing blade phenotype of SCCRO4^UAS.Tag:MYC, Scer\GAL4^ptc.PU

(Fu et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of SCCRO^{Scer\UAS.T:Ivir\HA1} but not SCCRO^DAD.Scer\UAS suppresses the small rough eye phenotype seen in flies with expression of SCCRO4^{Scer\UAS.T:Hsap\MYC} driven by Scer\GAL4^GMR.PF.

(Fu et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

SCCRO^DAD.Scer\UAS

SCCRO^DAD.UAS

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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