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General Information
Symbol
Dmel\ZyxΔ41
Species
D. melanogaster
Name
FlyBase ID
FBal0319347
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Mutagen
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Seven bp deletion introduces a frameshift at codon 103 of Zyx-PA, Zyx-PB and Zyx-PL.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

7bp deletion which introduces a frameshift at codon 103 (isoforms RA and RB), 41 (isoform RG), or 14 (isoform RH), resulting in a premature stop codon leading to a 19 to 108 amino acid residue peptide that lacks most of the wild-type Zyx sequence.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

ZyxΔ41/ZyxΔ41 adult flies are smaller and lighter compared to wild-type and have smaller and narrower wings but do not display any defects in eye development (number od inter-ommatidial cells in the pupal retina, photoreceptor differentiation as well as adult eye size are normal).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference

ZyxΔ41/ZyxΔ41 is an enhancer of visible | adult stage phenotype of dGC13

Suppressor of
Statement
Reference

ZyxΔ41/ZyxΔ41 is a suppressor of visible | adult stage phenotype of exe1

ZyxΔ41/ZyxΔ41 is a suppressor | partially of lethal phenotype of exe1

NOT Suppressor of
Statement
Reference

ZyxΔ41/ZyxΔ41 is a non-suppressor of lethal phenotype of ft8/ftG-rv

ZyxΔ41/ZyxΔ41 is a non-suppressor of visible | adult stage phenotype of hpo5.1

ZyxΔ41/ZyxΔ41 is a non-suppressor of visible | adult stage phenotype of ftG-rv

Phenotype Manifest In
Enhancer of
Statement
Reference
Suppressor of
NOT Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for ftG-rv/ftG-rv eyes (created by the EGUF method in otherwise heterozygous animals) can be partially suppressed by combination with ZyxΔ41/ZyxΔ41 but this does not affect the size of the mutant adult eyes.

The low rate of survival of ftG-rv/ft8 transheterozygotes to third instar larval stage (and never to adulthood), the loss of photoreceptor cells in the eye discs or the overgrowth of the wing disc cannot be suppressed by combination with ZyxΔ41/ZyxΔ41.

The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for ft8/ft8 eyes (created by the EGUF method in otherwise heterozygous animals) cannot be restored by combination with ZyxΔ41/ZyxΔ41.

The supernumerary inter-ommatidial cells in the pupal retina as well as the smaller size and altered eye shape in adults characteristic for exe1/exe1 eyes (created by the EGUF method in otherwise heterozygous animals) can be suppressed by combination with ZyxΔ41/ZyxΔ41.

The low survival rate of exe1/exe1 mutants to third instar larval stage can be improved by combination with ZyxΔ41/ZyxΔ41 and some of the double mutants can survive even to adulthood. The decreased number of photoreceptor cells in the eye discs characteristic for exe1/exe1 mutants is also restored in the surviving exe1;ZyxΔ41 double mutant third instar larvae.

The overgrowth of the wing discs characteristic for exe1/exAP50 transheterozygotes can be suppressed by combination with ZyxΔ41/ZyxΔ41.

The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for exAP50/exAP50 eyes (created by the EGUF method in otherwise heterozygous animals) can be suppressed by combination with ZyxΔ41/ZyxΔ41.

The supernumerary inter-ommatidial cells in the pupal retina phenotype characteristic for hpo5.1/hpo5.1 eyes (created by the EGUF method in otherwise heterozygous animals) can be partially suppressed by combination with ZyxΔ41/ZyxΔ41 but the overgrowth and folded shape of the adult eyes cannot be rescued.

The reduced size of both eye and wing discs characteristic for d1/dGC13 transheterozygote third instar larvae is further enhanced by combination with ZyxΔ41/ZyxΔ41.

The small eye phenotype characteristic for dGC13/dGC13 adult eyes (created by the EGUF method in otherwise heterozygous animals) cannot be suppressed by combination with ZyxΔ41/ZyxΔ41.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescued by

ZyxΔ41 is partially rescued by ZyxUbi-p63E.PG

ZyxΔ41 is partially rescued by ZyxUbi-p63E.PG

Comments

Expression of ZyxUbi-p63E.PG in the ZyxΔ41/ZyxΔ41 mutant background can partially restore the decreased body weight and fully suppress the small and narrow wing phenotype characteristic for ZyxΔ41/ZyxΔ41 adults.

The small wing phenotype displayed by ZyxΔ41/ZyxΔ41 adults can be fully rescued by expression of ZyxScer\UAS.cGa under the control of Scer\GAL4nub.PU in the mutant background, resulting in adult wings comparable in size to wild-type.

Flies expressing ZyxScer\UAS.T:Myr-Src42A under the control of Scer\GAL4nub.PU in a ZyxΔ41/ZyxΔ41 background have adult wings that are significantly bigger in size than wild-type.

Flies expressing ZyxΔ208-231.Scer\UAS.T:Myr-Src42A under the control of Scer\GAL4nub.PU in a ZyxΔ41/ZyxΔ41 background have adult wings that are comparable in size to wild-type.

Flies expressing ZyxΔ208-231.Scer\UAS under the control of Scer\GAL4nub.PU in a ZyxΔ41/ZyxΔ41 background have adult wings that are comparable in size to wild-type.

The small wing phenotype displayed by ZyxΔ41/ZyxΔ41 adults can be fully rescued by expression of ZyxScer\UAS.cGa under the control of Scer\GAL4nub.PU in the mutant background, resulting in adult wings comparable in size to wild-type.

The small wing phenotype displayed by ZyxΔ41/ZyxΔ41 adults can be fully rescued by expression of ZyxScer\UAS.T:Myr-Src42A under the control of Scer\GAL4nub.PU in the mutant background, resulting in adult wings that are significantly bigger in size than wild-type.

The small wing phenotype displayed by ZyxΔ41/ZyxΔ41 adults can be fully rescued by expression of ZyxΔ208-231.Scer\UAS.T:Myr-Src42A under the control of Scer\GAL4nub.PU in the mutant background, resulting in adult wings comparable in size to wild-type.

The small wing phenotype displayed by ZyxΔ41/ZyxΔ41 adults can be fully rescued by expression of ZyxΔ208-231.Scer\UAS under the control of Scer\GAL4nub.PU in the mutant background, resulting in adult wings that are comparable in size to wild-type.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
ZyxΔ41
Name Synonyms
Secondary FlyBase IDs
    References (1)