FB2025_01 , released February 20, 2025
Allele: Hsap\CRKLPickles.2.31.UAS
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General Information
Symbol
Hsap\CRKLPickles.2.31.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0319360
Feature type
allele
Associated gene
Hsap\CRKL
Associated Insertion(s)
Carried in Construct
P{UAS-Pickles.2.31}
Key Links
Transgenic product class
Mutagen
    Nature of the Allele
    Transgenic product class
    Mutagen
    Progenitor genotype
    Carried in construct
    P{UAS-Pickles.2.31}
    Cytology
    Description

    UASt regulatory sequences drive expression of a reporter of Abl activity. The reporter consists of a fragment of a characteristic Abl substrate Hsap\CRKL, sandwiched between the Venus and ECFP fluorescent proteins. Activated Abl phosphorylates the Y207 residue of the Hsap\CRKL fragment, and this can be detected with an anti-phospho Y207 antibody.

    (Sterne et al., 2015)
    Allele components
    Component
    Use(s)
    Regulatory region(s)
    UASt
    Encoded product / tool
    Hsap\CRKL
    Tagged with
    ECFP
    Venus
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Hsap\CRKLPickles.2.31.Scer\UAS
        Hsap\CRKLPickles.2.31.UAS
        Name Synonyms
        Secondary FlyBase IDs
          References (1)