FlyBase Allele Report: Dmel\mask[EY13048]

General Information

Symbol

Dmel\mask^EY13048

Species

D. melanogaster

Name

FlyBase ID

FBal0319553

Feature type

allele

Associated gene

Dmel\mask

Associated Insertion(s)

P{EPgy2}mask^EY13048

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Zhu et al., 2015)

Mutagen

Progenitor genotype

Associated Insertion(s)

P{EPgy2}mask^EY13048

Cytology

Description

Allele components

Component

Use(s)

Inserted element

P{EPgy2}

misexpression element

Regulatory region(s)

UASp

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3R:24,230,915..24,230,915 [-]

(Zhu et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by park²⁵, park^Δ21

(Zhu et al., 2015)

modeled by Pink1^B9

(Zhu et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 1 )

park[25]/park[Δ21] transheterozygotes were used as the disease model.

(Zhu et al., 2015)

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable (with mask^10.22)

(Zhu et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mask^EY13048/mask^10.22 is a suppressor | partially of abnormal flight phenotype of park^Δ21/park²⁵

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor | partially of abnormal flight phenotype of Pink1^B9

(Zhu et al., 2015)

Phenotype Manifest In

Suppressor of

Statement

Reference

mask^EY13048/mask^10.22 is a suppressor | partially of adult external thorax phenotype of park^Δ21/park²⁵

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor of mitochondrion | third instar larval stage phenotype of Pink1^B9

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor of larval somatic muscle cell | third instar larval stage phenotype of Pink1^B9

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor | partially of mitochondrion | adult stage phenotype of park^Δ21/park²⁵

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor | partially of indirect flight muscle cell phenotype of park^Δ21/park²⁵

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor of mitochondrion | third instar larval stage phenotype of park^Δ21/park²⁵

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor of larval somatic muscle cell | third instar larval stage phenotype of park^Δ21/park²⁵

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor | partially of adult external thorax phenotype of Pink1^B9

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor | partially of mitochondrion | adult stage phenotype of Pink1^B9

(Zhu et al., 2015)

mask^EY13048/mask^10.22 is a suppressor | partially of indirect flight muscle cell phenotype of Pink1^B9

(Zhu et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The indentations on the thorax of adult males hemizygous for Pink1^B9 as well as their reduced ability to fly can be partially suppressed, in a dose-dependent manner, by combination with mask^10.22/+ or mask^10.22/mask^EY13048 alleles, which leads to significantly lower penetrance of the thoracic phenotype and increased flight ability compared to Pink1^B9 mutants alone.

The disturbed morphology of both mitochondria and indirect flight muscles characteristic for adult Pink1^B9 hemizygote males is substantially suppressed by combination with mask^10.22/+ or mask^10.22/mask^EY13048 alleles.

The indentations on the thorax of adult park²⁵/park^Δ21 transheterozygotes as well as their reduced ability to fly can be partially suppressed, in a dose-dependent manner, by combination with mask^10.22/+ or mask^10.22/mask^EY13048 alleles, which leads to significantly lower penetrance of the thoracic phenotype and increased flight ability compared to park²⁵/park^Δ21 mutants alone.

The disturbed morphology of both mitochondria and indirect flight muscles characteristic for adult park²⁵/park^Δ21 transheterozygotes is substantially suppressed by combination with mask^10.22/+ or mask^10.22/mask^EY13048 alleles.

The enlarged or aggregated mitochondria phenotype observed in the body wall muscles of park²⁵/park^Δ21 transheterozygote third instar larvae is suppressed by combination with mask^10.22/mask^EY13048 alleles.

The enlarged or aggregated mitochondria phenotype observed in the body wall muscles of Pink1^B9 hemizygous male third instar larvae is suppressed either by combination with mask^10.22/mask^EY13048 alleles or by ectopic expression of park^Scer\UAS.cGa under the control of Scer\GAL4^how-24B.

(Zhu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

20853

y¹ w^67c23; P{EPgy2}mask^EY13048

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mask^EY13048

(Zhu et al., 2015)

mask^P

(Zhu et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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