FB2025_04 , released October 2, 2025
Allele: Dmel\glob1UAS.cYa
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General Information
Symbol
Dmel\glob1UAS.cYa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Yadav
FlyBase ID
FBal0319589
Feature type
allele
Associated gene
Dmel\glob1
Associated Insertion(s)
Carried in Construct
P{UAS-glob1.Y}
Also Known As
UAS-glob1
Key Links
Transgenic product class
wild_type
(Yadav et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Yadav et al., 2015)
Mutagen
in vitro construct
(Yadav et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-glob1.Y}
Cytology
Description

UASt regulatory sequences drive expression of the 5'UTR and coding sequence of glob1.

(Yadav et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
glob1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  tauopathy
      modeled by Hsap\MAPTV337M.UAS
      (Nisha and Sarkar, 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ectopic expression of glob1Scer\UAS.cYa under the control of Scer\GAL4Act5C.PI does not significantly increase lethality in any of the developmental stages compared to wild-type controls and does not cause formation of melanotic masses.

      (Yadav et al., 2015)
      External Data
      Interactions
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Act5C.PI/glob1UAS.cYa rescues glob1HMS01556

      (Yadav and Sarkar, 2016)

      Scer\GAL4btl.PS/glob1UAS.cYa rescues glob1HMS01556

      (Yadav et al., 2015)

      Scer\GAL4Act5C.PI/glob1UAS.cYa rescues glob1HMS01556

      (Yadav et al., 2015)
      Comments

      The abnormal distribution of follicle cells (multilayering) and nurse cells in the egg chambers from females expressing glob1HMS01556 under the control of Scer\GAL4Act5C.PI can be rescued by co-expression of glob1UAS.cYa.

      (Yadav and Sarkar, 2016)

      The defects in morphology of the tracheal system as well as in the tracheal liquid clearance observed in first instar larvae expressing glob1HMS01556 under the control of either Scer\GAL4Act5C.PI or Scer\GAL4btl.PS is fully rescued by co-expression of glob1Scer\UAS.cYa.

      (Yadav et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      glob1Scer\UAS.cYa
      glob1UAS.cYa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Yadav
      Secondary FlyBase IDs
        References (4)