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General Information
Symbol
Dmel\ken141
Species
D. melanogaster
Name
FlyBase ID
FBal0319631
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Mutations Mapped to the Genome
     
    Type
    Location
    Additional Notes
    References
    Associated Sequence Data
    DNA sequence
    Protein sequence
     
     
    Progenitor genotype
    Cytology
    Nature of the lesion
    Statement
    Reference

    Insertion within ken, 59bp downstream of the transcription start site.

    Insertion components
    P{GAL4}ken141
    Product class / Tool use(s)
    Expression Data
    Reporter Expression
    Additional Information
    Statement
    Reference
     
    Marker for
    Reflects expression of
    Reporter construct used in assay
    Human Disease Associations
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Phenotypic Data
    Phenotypic Class
    Phenotype Manifest In
    Detailed Description
    Statement
    Reference

    Flies homozygous for ken141 undergo embryonic development but fail to hatch, but no defects were observed in the number of neurons or their projections.

    ken141/ken1 transheterozygotes display the same adult phenotypes (abnormal, often missing, genitalia; unpigmented aristae; wings held out away from the body) characteristic or viable ken mutants. No obvious morphological defects are seen in the giant fiber neurons.

    Homozygous ken1 mutant adults as well as ken1/Df(2R)or-BR11 hemizygotes and ken1/ken141 transheterozygotes show defective light-off escape behavior, phototaxis and general locomotor activity compared to wild-type controls, with the hemizygotes showing the most severe phenotype in all assays.

    Both adult ken1 homozygotes and ken141/ken1 transheterozygotes show defects in the electrophysiology of the giant fibre system: they display longer response latencies and a lower percentage following to 10 stimuli at 250Hz in tergo trochantal muscles compared to wild-type controls. When stimulated directly, the muscles of ken1 mutants respond with the correct short latency characteristic for normal neuromuscular junctions.

    External Data
    Interactions
    Show genetic interaction network for Enhancers & Suppressors
    Phenotypic Class
    Phenotype Manifest In
    Additional Comments
    Genetic Interactions
    Statement
    Reference
    Xenogenetic Interactions
    Statement
    Reference
    Complementation and Rescue Data
    Fails to complement
    Comments
    Images (0)
    Mutant
    Wild-type
    Stocks (0)
    Notes on Origin
    Discoverer
    External Crossreferences and Linkouts ( 0 )
    Synonyms and Secondary IDs (1)
    Reported As
    Symbol Synonym
    ken141
    Name Synonyms
    Secondary FlyBase IDs
      References (1)