FB2025_01 , released February 20, 2025
Allele: Dmel\foiC153
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General Information
Symbol
Dmel\foiC153
Species
D. melanogaster
Name
FlyBase ID
FBal0319772
Feature type
allele
Associated gene
Dmel\foi
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Nucleotide substitution: C2614T.

    (Carrasco-Rando et al., 2016)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    3L:8,532,977..8,532,977 [+]
    Nucleotide change:

    C8532977T

    Reported nucleotide change:

    C2614T

    Amino acid change:

    Q665term | foi-PA; Q665term | foi-PB; Q665term | foi-PC; Q665term | foi-PD

    Comment:

    Reported as a C to T change at nucleotide 2614 of the foi cDNA, assumed to be RE41071. Mutation mapped to position 2615 of the cDNA, which corresponds to the C of a Glutamine codon.

    (Carrasco-Rando et al., 2016)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        foiC153/foiC153 mutant embryos display defective muscle patterning with missing muscles, morphological defects in dorsal, lateral and ventral groups of muscles, and a fusion defect shown by reduced size of the remaining muscles. The visceral mesoderm is defective, with loss of the gastric caeca and the anterior gut constriction, misplaced middle constriction, and in many cases a delay in the formation or failure to complete the posterior gut constriction, as compared to wild type.

        (Carrasco-Rando et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        foiC153 is rescued by foiUAS.cCa/Scer\GAL4Mef2.PU

        (Carrasco-Rando et al., 2016)
        Comments

        Expression of foiScer\UAS.cCa under the control of Scer\GAL4Mef2.PU fully rescues the muscle patterning and fusion, visceral mesoderm, and defective fusion-competent myoblast differentiation phenotypes of foiC153/foiC153 mutants.

        (Carrasco-Rando et al., 2016)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        foiC153
        (Carrasco-Rando et al., 2016)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)