FB2025_01 , released February 20, 2025
Allele: Dmel\SdcUAS.FL.Tag:MYC
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General Information
Symbol
Dmel\SdcUAS.FL.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0319779
Feature type
allele
Associated gene
Dmel\Sdc
Associated Insertion(s)
Carried in Construct
P{UAS-Sdc.FL}
Key Links
Transgenic product class
wild_type
(Nguyen et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Nguyen et al., 2016)
Mutagen
in vitro construct
(Nguyen et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Sdc.FL}
Cytology
Description

UAS regulatory sequences drive expression of full-length Sdc. The protein is tagged in the extracellular domain with a 5x Tag:MYC tag.

(Nguyen et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sdc
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SdcScer\UAS.FL.T:Hsap\MYC driven post-synaptically by Scer\GAL4how-24B or presynaptically by Scer\GAL4elav.PU leads to a significant increase in the number of boutons per neuromuscular junction, compared to controls.

      (Nguyen et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Sdc10608/Df(2R)48 third instar larvae (in which Sara function has been rescued by SaraUbi.PJ) have a decrease in the number of boutons per neuromuscular junction, compared to controls; this phenotype is completely rescued by pre- (Scer\GAL4elav.PU) or post- (Scer\GAL4how-24B) synaptic expression of SdcScer\UAS.FL.T:Hsap\MYC, or pre- (and partial rescue with post-) synaptic expression of SdcScer\UAS.cJa.

      (Nguyen et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav.PU/SdcUAS.FL.Tag:MYC rescues Sdc10608/Df(2R)48

      (Nguyen et al., 2016)

      Scer\GAL4how-24B/SdcUAS.FL.Tag:MYC rescues Sdc10608/Df(2R)48

      (Nguyen et al., 2016)
      Comments

      Sdc10608/Df(2R)48 third instar larvae (in which Sara function has been rescued by SaraUbi.PJ) have a decrease in the number of boutons per neuromuscular junction, compared to controls; this phenotype is completely rescued by pre- (Scer\GAL4elav.PU) or post- (Scer\GAL4how-24B) synaptic expression of SdcScer\UAS.FL.T:Hsap\MYC.

      (Nguyen et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SdcScer\UAS.FL.T:Hsap\MYC
      SdcUAS.FL.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)