FB2025_02 , released April 17, 2025
Allele: Dmel\NmnatUAS.PD
Open Close
General Information
Symbol
Dmel\NmnatUAS.PD
Species
D. melanogaster
Name
FlyBase ID
FBal0319903
Feature type
allele
Associated gene
Dmel\Nmnat
Associated Insertion(s)
Carried in Construct
P{UAS-Nmnat.PD}
Also Known As
UAS-PD
Key Links
Transgenic product class
wild_type
(Ruan et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Ruan et al., 2015)
Mutagen
in vitro construct
(Ruan et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Nmnat.PD}
Cytology
Description

UAS regulatory sequences drive expression of the Nmnat PD isoform.

(Ruan et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Nmnat
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  autosomal dominant cerebellar ataxia
      modeled by Hsap\ATXN182Q.UAS
      (Ruan et al., 2015)
      ameliorates  tauopathy
      modeled by Hsap\MAPTR406W.UAS
      (Ma et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of NmnatScer\UAS.PD partially suppresses the age-dependent decline in climbing performance and signs of increased apoptosis in the brain in flies with expression of Hsap\ATXN182Q.Scer\UAS driven by Scer\GAL4nrv2.PS.

      (Ruan et al., 2015)
      Complementation and Rescue Data
      Rescues

      Scer\GAL4Act.PU/NmnatUAS.PD rescues NmnatΔ4790-1

      (Ruan et al., 2015)
      Comments

      Expression of NmnatScer\UAS.PD driven by Scer\GAL4Act.PU rescues lethality in NmnatΔ4790-1/NmnatΔ4790-1 mutants.

      (Ruan et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      NmnatScer\UAS.PD
      NmnatUAS.PD
      Name Synonyms
      Secondary FlyBase IDs
        References (3)