FB2025_01 , released February 20, 2025
Allele: Dmel\mTorUAS.cUa
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General Information
Symbol
Dmel\mTorUAS.cUa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Unknown
FlyBase ID
FBal0320057
Feature type
allele
Associated gene
Dmel\mTor
Associated Insertion(s)
Carried in Construct
P{UAS-mTor.U}
Also Known As
UAS-mTOR, UAS-dTOR
Key Links
Transgenic product class
wild_type
(Bargiela et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Bargiela et al., 2015)
Mutagen
in vitro construct
(Bargiela et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-mTor.U}
Cytology
Description

UAS regulatory sequences drive expression of Tor.

(Bargiela et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
mTor
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  myotonic dystrophy type 1
      modeled by Zzzz\CTGi480.UAS.cGa
      (Bargiela et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TorScer\UAS.cUa under the control of Scer\GAL4hs.PU results in a significant increase in muscle area in dorsoventral sections of the thorax, and increased apoptosis, but no significant change in autophagy in adult muscle, after induction via heat shock, as compared with controls.

      (Bargiela et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of TorScer\UAS.cUa fully suppresses the decreased muscle area and increased autophagy and apoptosis seen in flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4hs.PU in response to heat shock; and partially rescues the shortened lifespan of flies expressing Zzzz\CTGi480.Scer\UAS.cGa under the control of Scer\GAL4Mhc.PW.

      (Bargiela et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      TorScer\UAS.cUa
      TorUAS.cUa
      mTorUAS.cUa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Unknown
      Secondary FlyBase IDs
        References (6)