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General Information
Symbol
Paer\ExoSGAP.UAS
Species
P. aeruginosa
Name
FlyBase ID
FBal0321127
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of the Paer\ExoS GTPase activating (GAP) domain.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4GMR.PF have slightly rough eyes.

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4en-e16E have a few additional veins in the posterior part of the wing.

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4GMR.PF have slight defects in ommatidial organisation with occasional loss of misoriented bristles.

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of either Scer\GAL4srp.D.cCa or Scer\GAL4hs.PB show reduced resistance to infection by P.aeruginosa (both the cytotoxic CHA strain and the mutant CHA::exsA strain) (infection by septic injury).

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4yolk show wild-type levels of resistance to infection by P.aeruginosa(both the cytotoxic CHA strain and the mutant CHA::exsA strain) (infection by septic injury).

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of either Scer\GAL4srp.D.cCa or Scer\GAL4da.G32 show reduced resistance to oral infection by the P.aeruginosa CHA strain.

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4srp.D.cCa show reduced phagocytosis of injected bacteria compared to control flies (when assayed 40 minutes after injection).

Flies expressing Zzzz\ExoSGAP.Scer\UAS under the control of either Scer\GAL4srp.D.cCa or Scer\GAL4da.G32 show reduced resistance to infection by S.aureus (infection by septic injury).

Circulating plasmatocytes from third instar larvae expressing Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4srp.D.cCa or Scer\GAL4crq.PU show a reduced phagocytic index (for dead E.coli and dead S.aureus) compared to control plasmatocytes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of Zzzz\ExoSGAP.Scer\UAS suppresses the rough eye phenotype caused by expression of Rac2Scer\UAS.cARa under the control of Scer\GAL4GMR.PF.

Co-expression of Zzzz\ExoSGAP.Scer\UAS suppresses the wing phenotype caused by expression of Rac2Scer\UAS.cARa under the control of Scer\GAL4en-e16E.

The increased sensitivity to P.aeruginosa following oral infection that is seen in flies expressing Rac2Scer\UAS.cARa under the control of Scer\GAL4da.G32 is suppressed by co-expression of Zzzz\ExoSGAP.Scer\UAS.

The viability of flies expressing Rac1Scer\UAS.cLa under the control of Scer\GAL4GMR.PF is enhanced to 50% by co-expression of Zzzz\ExoSGAP.Scer\UAS. In addition, the eye morphology of the surviving adults is restored towards wild type.

Co-expression of Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4GMR.PF restores the eye morphology to wild type in Cdc42GMR.PN flies.

Co-expression of Zzzz\ExoSGAP.Scer\UAS under the control of Scer\GAL4GMR.PF restores the eye morphology to wild type in Rho1GMR.PH flies.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Paer\ExoSGAP.Scer\UAS
Paer\ExoSGAP.UAS
Zzzz\ExoSGAP.Scer\UAS
Name Synonyms
Secondary FlyBase IDs
  • FBal0320513
  • FBal0219715
References (3)