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General Information
Symbol
Hpyl\cagAUAS.Tag:HA
Species
H. pylori
Name
FlyBase ID
FBal0321250
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of Hpyl\cagA tagged at the N-terminal end with Tag:HA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF results in disorganisation of the retinal epithelium. The normal crystalline structure of the ommatidium is disturbed and normal cell shapes and neighbour relationships are perturbed. The phenotype is dosage-dependent, appearing more severe in flies expressing two copies of Zzzz\cagAScer\UAS.T:Ivir\HA1 compared to one copy.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4hs.PB suppresses the lethality seen in dos1.46/dos2.42 mutants. 89% of the expected number of pupae are seen, compared to only 33% in homozygous dos1.46 mutants.

Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PF increases dos1.46 mutant clone size in the eye. The clones are much larger and contain increased numbers of photoreceptors.

Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of either Scer\GAL4GMR.PF or Scer\GAL4hs.PB does not significantly increase the number of photoreceptors seen in csw13-87 mutant larval eye discs.

Expression of Zzzz\cagAScer\UAS.T:Ivir\HA1 under the control of either Scer\GAL4GMR.PF or Scer\GAL4hs.PB does not significantly increase the number of photoreceptors seen in csw1 mutant larval eye discs.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hpyl\cagAScer\UAS.T:Ivir\HA1
Hpyl\cagAUAS.Tag:HA
Zzzz\cagAScer\UAS.T:Ivir\HA1
Name Synonyms
Secondary FlyBase IDs
  • FBal0320636
  • FBal0280226
References (2)