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General Information
Symbol
Dmel\tapGal4
Species
D. melanogaster
Name
FlyBase ID
FBal0321568
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

The tap open reading frame has been replaced by sequence encoding a GAL4 driver, such that GAL4 is expressed under the control of endogenous tap regulatory sequences.

Insertion components
TI{GAL4}tapGal4
Product class / Tool use(s)
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

tapGal4/tapGal4 embryos show no obvious morphological defects, with the number and fate of neurons and glia not significantly altered in the CNS or PNS, compared to controls.

tapGal4/+ heterozygotic adults show a significant increase in the frequency of mild beta lobe axon midline crossing defects (seen from early pupal stages and in the adult), missing alpha lobes (in some of these cases, the beta lobe appears to branch into two bundles) and loss of dorsal projection of alpha/beta neurons in the mushroom bodies compared to wild type. In around one third of tapGal4/tapGal4 mushroom body clones, beta axons project beyond the mushroom body beta lobe domains (in severe cases, axons cross the midline and project to the contralateral lobe).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, enhanceable by dsh1/dsh[+]

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, enhanceable by dsh[+]/dsh6

NOT Enhanced by
Statement
Reference

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by Dscam121/Dscam1[+]

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by Abl4/Abl[+]

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by Appld/Appl[+]

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by stan[+]/stanE59

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by Vangstbm-6/Vang[+]

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by Wnt5400/Wnt5[+]

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by drl[+]/drlRed2

tapGal4 has neuroanatomy defective | dominant | adult stage phenotype, non-enhanceable by sli2/sli[+]

Phenotype Manifest In
Enhanced by
Statement
Reference
NOT Enhanced by
Statement
Reference

tapGal4 has adult mushroom body beta-lobe | adult stage phenotype, non-enhanceable by Dscam121/Dscam1[+]

tapGal4 has adult mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Abl4/Abl[+]

tapGal4 has adult mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Appld/Appl[+]

tapGal4 has adult mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by stan[+]/stanE59

tapGal4 has adult mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Wnt5400/Wnt5[+]

tapGal4 has adult mushroom body beta-lobe | adult stage phenotype, non-enhanceable by drl[+]/drlRed2

tapGal4 has adult mushroom body beta-lobe | adult stage phenotype, non-enhanceable by sli2/sli[+]

Additional Comments
Genetic Interactions
Statement
Reference

Presence of Dscam121/+, drlRed2/+, Abl4/+, Appld/+, stanE59/+, Vangstbm-6/+, Wnt5400/+ or sli2/+ does not significantly enhance frequency of mushroom body beta lobe axon overgrowth defects in tapGal4/+ brains. Presence of dsh1/+ or dsh6/+ significantly enhances frequency of mushroom body beta lobe axon overgrowth defects (midline crossing) in tapGal4/+ brains; dsh6/+ also significantly enhances frequency of missing alpha lobes.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of tapScer\UAS.T:Avic\GFP (driven by Scer\GAL4tap-Gal4) rescues lethality and mushroom body defects in tapGal4/tapGal4 flies (or beta axon overgrowth in mutant clones).

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (1)