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General Information
Symbol
Dmel\cicΔC2.UAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0321698
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of cic carrying a deletion of the MAPK docking site-C2 motif. The protein is tagged with Tag:HA.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The regeneration-associated proliferation normally observed in adult midgut upon Pseudomonas entomophila enteric infection is inhibited by cicΔC2.Scer\UAS.T:Ivir\HA1 expression: the growth of somatic intestinal stem cell flip-out clones expressing cicΔC2.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4esg-NP5130 in which all the progeny of the intestinal stem cells born during the regeneration period are visibly marked (using tub-Gal80[ts] to limit the time of expression/clone induction) is significantly reduced compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The increase in the adult midgut intestinal stem cell proliferation characteristic for flies expressing either pntP1.Scer\UAS or pntP2.Scer\UASunder the control of Scer\GAL4esg-NP5130 (using tub-Gal80[ts] to limit the time of the transgene expression) is not suppressed by co-expression of cicΔC2.Scer\UAS.T:Ivir\HA1.

The overgrowth and increased mitotic rate of intestinal stem cell somatic flip-out clones expressing btl::EgfrScer\UAS.T:λ\cI-DD under the control of Scer\GAL4esg-NP5130 (using tub-Gal80[ts] to limit the time of expression/clone induction) in the adult midgut is suppressed by co-expression of cicΔC2.Scer\UAS.T:Ivir\HA1; the number of mitotic cells per adult midgut is even lower than in wild-type.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
cicΔC2.Scer\UAS.T:Ivir\HA1
cicΔC2.UAS.Tag:HA
Name Synonyms
Secondary FlyBase IDs
    References (2)