Over-expression of Uba1 with Uba1UY3010 under the control of Scer\GAL4vg.PM attenuates the notched wing phenotype and lethality observed in flies expressing Mmus\BaxScer\UAS.cGa under the control of Scer\GAL4vg.PM.
Co-expression of Uba1EP2375 almost completely suppresses the notched wing phenotype observed in adults, and reduces the number of apoptotic cells in third instar wing discs in flies expressing Mmus\BaxScer\UAS.cGa under the control of Scer\GAL4vg.PM.
A mgeB10 heterozygous background partially suppresses the wing phenotypes found upon expression of Mmus\BaxScer\UAS.cGa in the wing under the control of Scer\GAL4vg.PM. A shift in phenotype distribution from about 60% of strong and about 40% of intermediate phenotypes in the control cross to 30% of strong and about 70% of intermediate phenotypes in these double mutants.
A unc-4503692 heterozygous background enhances the wing phenotypes found upon expression of Mmus\BaxScer\UAS.cGa in the wing under the control of Scer\GAL4vg.PM. There is a significant increase from 60% to 90% of strong phenotypes (compared to controls) and a decrease from 40% to 10% of intermediate phenotypes. This shift in phenotype distribution reflects an enhancement of the Mmus\BaxScer\UAS.cGa-induced phenotype thus showing an increase of Mmus\BaxScer\UAS.cGa-induced cell death.
The eye ablation phenotype of Scer\GAL4GMR.PF, Mmus\BaxScer\UAS.cGb is partially restored in a debclKO-unspecified heterozygous background and nearly fully restored in a debclKO-unspecified homozygous background.
Ubiquitous co-expression of Hsap\BCL2Scer\UAS.cGa and Mmus\BaxScer\UAS.cGb under the control of Scer\GAL4GMR.PF results in a pattern of cell death similar to flies expressing Hsap\BCL2Scer\UAS.cGa alone.
Co-expression of Hsap\BCL2Scer\UAS.cGa in Mmus\BaxScer\UAS.cGb-expressing flies at 18[o]C induces a decrease in the ratio of strong wing phenotypes as opposed to intermediate and weak phenotypes and an increase of the ratio of weak wing phenotypes as opposed to intermediate and strong phenotypes. No significant effect was observed at 21 and 25[o]C. The structure of the wing is partially restored in these double mutants.