Open Close
General Information
Symbol
Dmel\Ank2XL-ΔC
Species
D. melanogaster
Name
FlyBase ID
FBal0322822
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
deletion
Comment:

Genomic fragment corresponding to residues 10722-11629 of annotated isoforms Ank2-PU and Ank2-PAA deleted. Position of deletion endpoints on reference sequence inferred from reported primer sequences.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

Genomic fragment encompassing the Ank2 locus (derived from BAC clone BACR03I22) in which sequence corresponding to the C-terminal end of the the XL protein isoform (amino acid residues 10723-11628) has been deleted. Sequence encoding the L protein isoform is unaffected.

Allele components
Product class / Tool use(s)
Regulatory region(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Ank2XL-ΔC in a Ank2f00518/Ank2f00518 background in larvae results in neuromuscular junctions exhibiting defective microtubule organization and synapse morphology, and the type 1b axons innervating NMJs exhibit aberrant axonal microtubule accumulations, as compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Suppressor of
Statement
Reference
Phenotype Manifest In
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of Ank2XL-ΔC in a Ank2f00518/Ank2f00518 mutant background fails to rescue the decreased microtubule core filament area seen in futschK68/futschK68 mutant larval neuromuscular junctions.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Ank2XL-ΔC
Name Synonyms
Secondary FlyBase IDs
    References (1)