Open Close
General Information
Symbol
Dmel\Dop2RΔ1
Species
D. melanogaster
Name
FlyBase ID
FBal0322964
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference
32,386bp deletion that removes part of Dop2R (and all of the neighbouring CG17003 gene).
Caused by aberration
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Adult Dop2RΔ1 homozygotes as well as Dop2RΔ1/Df(1)BSC587 and Dop2RΔ1/Dop2RΔ2 transheterozygotes show significantly decreased 3 min short-term memory in an aversive olfactory memory assay compared to controls. The shock and odor avoidance of Dop2RΔ1 homozygotes is normal. Dop2RΔ1 homozygotes show decreased memory due to strongly reduced consolidated (amnestic cooling resistant) memory at both 3 hr and 5 min post-training (the labile, amnestic cooling sensitive, memory is unaffected).
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
The reduced 3 hr olfactory memory characteristic for Dop2RΔ1 homozygous adults is decreased further by expression of rutVDRC.cUa under the control of Scer\GAL4elav.PU in the mutant background as the amnestic cooling sensitive memory component is reduced in addition to the amnesia-resistant component. Neither the total olfactory memory of the mutants nor any of its components (amnesia resistant or sensitive) is affected by expression of dncdsRNA.Scer\UAS.WIZ.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
The defective short-term memory (3 min) displayed by Dop2RΔ1 homozygotes in an aversive olfactory assay is fully rescued by expression of Dop2RScer\UAS.cSa under the control of either Scer\GAL4elav.PU or Scer\GAL4Mef2.247 (together with tub-Gal80[ts] to limit the expression to adult stage) in the mutant background. The decrease in 3 hr olfactory memory due to reduced amnestic cooling resistant memory component also observed in the Dop2RΔ1 mutants is rescued by expression of Dop2RScer\UAS.cSa under the control of any of the following: Scer\GAL4Mef2.247, Scer\GAL417d or Scer\GAL4NP1131, whereas expression under any of these drivers: Scer\GAL4ple.PF, Scer\GAL4Orco.PU, Scer\GAL4GH298, Scer\GAL4GH146, Scer\GAL4c320 has no effect on the mutant phenotype.
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Dop2RΔ1
Name Synonyms
Secondary FlyBase IDs
    References (1)